MABF465

Anti-KLRG1 Antibody (mouse), APC, clone 2F1

clone 2F1, 0.2 mg/mL, from hamster(Syrian)

• Sinônimo(s): Killer cell lectin-like receptor subfamily G member 1, Mast cell function-associated antigen 2F1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: hamster (Syrian)
• Nível de qualidade: 100
• conjugado: Allophycocyanin conjugate
• forma do anticorpo: purified antibody
• tipo de produto de anticorpo: primary antibodies
• clone: 2F1, monoclonal
• reatividade de espécies: mouse
• concentração: 0.2 mg/mL
• técnica(s): flow cytometry: suitable; immunoprecipitation (IP): suitable
• Isotipo: IgG
• nº de adesão UniProt: O88713
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: mouse ... Klrg1(50928)

Descrição

Descrição geral

The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations.

This golden syrian hamster monoclonal antibody Anti-KLRG1 (mouse), APC, clone 2F1 validated for use in IP & Flow Cytometry for the detection of KLRG1.

Qualidade

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.06 μg of this antibody detected KLRG1 in one million C57Bl/6 splenocytes.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): nwg