MABF271

Anti-FPR1/2 Antibody, clone NFPR1

clone NFPR1, from mouse

• Sinônimo(s): Anti-Formyl Peptide Receptor 1/2, FMLP1/2, fMet-Leu-Phe receptor, fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: NFPR1, monoclonal
• reatividade de espécies: human
• técnica(s): flow cytometry: suitable; immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• Isotipo: IgG1κ
• nº de adesão NCBI: NP_001180235
• nº de adesão UniProt: P21462
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... FPR1(2357)

Descrição

Descrição geral

N-formy peptide receptor 1 (also known as N-formylpeptide chemoattractant receptor or fMet-Leu-Phe receptor) & 2 (also known as RFP, FMLP-R-I, Lipoxin A4 receptor, LXA4 receptor, FMLP-related receptor I, Formyl peptide receptor-like 1) are multi-pass cell membrane G protein-coupled receptors (GPCRs) encoded by the FPR1 (also known as FPR and FMLP) and FPR2 (also known as FPR2 and FMLP-R-II) gene in human, respectively. The FPR1 gene encodes the high-affinity, and FPR2 the low-affinity, receptor for N-formyl-methionyl peptides (FMLP). Both receptors mediate FMLP-induced activation of neutrophils.

Especificidade

This antibody is epitope mapped, recognizing cytoplasmic c-terminal tail residues of FPR1 (305-GQDFRERLI-313) and of FPR2 (306- GQDFRERLI-314) (Riesselman, M., et al. (2007). J. Immunol. 179:2520-2531).

Imunogênio

Epitope: FPR1 (305-GQDFRERLI-313) and FPR2 (306- GQDFRERLI-314)

His-tagged recombinant protein corresponding to the FPR1 (305-GQDFRERLI-313) and FPR2 (306- GQDFRERLI-314) of human FPR1/2.

Aplicação

Anti-FPR1/2 Antibody, clone NFPR1 is an antibody against FPR1/2 for use in Western Blotting, Flow Cytometry, Immunocytochemistry, Immunoprecipitation.

Flow Cytometry Analysis: A representative lot detected FPR1/2 in human neutraphils (Riesselman, M., et al. (2007). J. Immunol. 179:2520-2531).
Immunocytochemistry Analysis: A representative lot detected FPR1/2 in human neutraphils (Riesselman, M., et al. (2007). J. Immunol. 179:2520-2531).
Immunoprecipitation Analysis: A representative lot immunoprecipitated FPR1/2 in neutraphils (Maaty, W.S., et al. (2013). JBC. 288(38):27042-27058).
Western Blotting Analysis: A representative lot detected FPR1/2 in neutraphils (Maaty, W.S., et al. (2013). JBC. 288(38):27042-27058).

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Qualidade

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected FPR1/2 in 10 µg of THP-1 cell lysate.

Descrição-alvo

~38 kDa observed. Uncharacterized band(s) may appear in some lysates.

forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Outras notas

Concentration: Please refer to lot specific datasheet.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable