G8918

Anti-GRP78/BiP (GL-19) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinônimo(s): Anti-78-kDa Glucose-Regulated Protein, Anti-Immunoglobulin Heavy Chain Binding Protein
• Número MDL: MFCD01865530
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: IgG fraction of antiserum
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen 78 kDa
• reatividade de espécies: mouse, hamster, human
• validação aprimorada: independent; Learn more about Antibody Enhanced Validation
• técnica(s): immunocytochemistry: 1:1,000 using mouse fibroblasts NIH3T3 cells; microarray: suitable; western blot: 1:3,000 using human epitheloid carcinoma HeLa whole cell extract
• nº de adesão UniProt: P11021
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... HSPA5(3309) ; mouse ... Hspa5(14828)

Descrição

Descrição geral

GRP78/BiP is a Ca²⁺-binding molecular chaperone located in the endoplasmic reticulum (ER). It is a highly conserved protein.

Aplicação

Anti-GRP78/BiP (GL-19) antibody produced in rabbit has been used in:

• western blotting
• immunocytochemistry
• immunohistochemistry

Ações bioquímicas/fisiológicas

GRP78 (78-kDa glucose-regulated protein) is essential for cell viability. GRP78/BiP is induced by stress-inducing agents or by conditions that adversely affect endoplasmic reticulum(ER) function, including oxidative stress, chemical toxicity, Ca²⁺ ionophores, inhibition of the ER Ca²⁺ -ATPase, inhibitors of glycosylation and hypoxia. GRP78/BiP is critical for maintenance of Ca²⁺ homeostasis and the prevention of apoptosis. GRP78/BiP levels are reduced in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with mis-sense mutations in presenilin-1 (PS-1).

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable