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Documentos Principais

MABC536

Sigma-Aldrich

Anti-Vasohibin-2, clone 5E3 Antibody

clone 5E3, 1 mg/mL, from mouse

Sinônimo(s):

Vasohibin-2, Vasohibin-like protein

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

5E3, monoclonal

reatividade de espécies

human, mouse

concentração

1 mg/mL

técnica(s)

immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG1κ

nº de adesão NCBI

NP_001129946

nº de adesão UniProt

Q86V25

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... VASH2(79805)

Descrição geral

Vasohibin-2, also known as Vasohibin-like protein, and encoded by the gene VASH2/VASHL, is a developmental regulator protein of angiogenesis induced by VEGF and present in various embryonic organs at six to 12 twelve weeks of development in humans. Vasohibin-2 acts as an angiogenesis inhibitor and is thought to help regulate organ vessel formation and maturation. In cancer, Vascohibin-2 appears to act to promote angiogenesis and is expressed in many cancers. In cancer cells, there are two isoforms. VASH2 (with 355 amino acid residues) is located in the cytoplasm while VASH2 (with 311 amino acid residues) is located in the nucleus. The former was found to be a relatively low abundance protein.

Imunogênio

KLH-conjugated linear peptide corresponding to human Vasohibin 2.

Aplicação

Anti-Vasohibin-2 antibody, clone 5E3 is an antibody against Vasohibin-2 for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Vasohibin 2 in human placenta tissue.
Immunohistochemistry Analysis: A representative lot detected Vasohibin 2 in human and mouse embryonic lung tissue (Shibuya, T., et al. (2006). American Heart Association. 26:1051-1057).

Qualidade

Evaluated by Western Blotting in HUVEC cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Vasohibin 2 in 10 µg of HUVEC cell lysate.

Descrição-alvo

~40 kDa observed. Uncharacterized band(s) may appear in some lysates.

forma física

Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives .

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Takumi Shibuya et al.
Arteriosclerosis, thrombosis, and vascular biology, 26(5), 1051-1057 (2006-03-11)
We recently isolated vasohibin, a novel vascular endothelial growth factor (VEGF)-inducible endothelium-derived angiogenesis inhibitor. Our aim is to find DNA sequences homologous to vasohibin and determine their expression profile. By the search of DNA sequences in the database, we found
Siem van der Laan et al.
Cell reports, 29(12), 4159-4171 (2019-12-19)
The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin detyrosinating activity. Moreover, we

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