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Merck
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Key Documents

MAB5540

Sigma-Aldrich

Anti-Olig1 Antibody

ascites fluid, Chemicon®

Sinônimo(s):

Oligo1, Oligodendrocyte transcription factor 1

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

forma do anticorpo

ascites fluid

tipo de produto de anticorpo

primary antibodies

clone

monoclonal

reatividade de espécies

human, mouse, rat

fabricante/nome comercial

Chemicon®

técnica(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG2b

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... OLIG1(116448)
rat ... Olig1(60394)

Descrição geral

Olig-1 is a bHLH transcription factor that is expressed by oligodendrocytes in the brain where it promotes oligodendrocyte formation and maturation. Olig1 cooperates with Olig2 to establish the pMN domain of the embryonic neural tube.

Especificidade

Oligodendrocyte marker Olig1. The antibody typically stains cell in either the cytoplasm or nucleus depending on cell type. Staining will be present in the nucleus of remyelinating oligodendrocytes.

Imunogênio

Fusion protein from mouse Olig1.

Aplicação

Anti-Olig1 Antibody is an antibody against Olig1 for use in WB, IC, IH.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

forma física

Liquid ascites fluid.

Armazenamento e estabilidade

Maintain at -20degC in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Nota de análise

Control
Positive control: Corpus callosium Negative control: skin or non-neural organs

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Olga Britanova et al.
Developmental biology, 298(1), 299-311 (2006-08-12)
Projection neurons of the developing cerebral cortex are generated in the cerebral ventricular zone and subsequently move to the developing cortical plate via radial migration. Conversely, most inhibitory interneurons originate in the ganglionic eminences and enter the developing cortical plate
Mario Marotta et al.
Stem cell research, 22, 33-42 (2017-06-05)
Despite benefits of prenatal in utero repair of myelomeningocele, a severe type of spina bifida aperta, many of these patients will still suffer mild to severe impairment. One potential source of stem cells for new regenerative medicine-based therapeutic approaches for
Hong Zhao et al.
Molecular medicine reports, 20(5), 4603-4611 (2019-11-09)
The differentiation and maturation of oligodendrocyte precursor cells (OPCs) is important for remyelination in the central nervous system. Nevertheless, this process is often limited and incomplete in ischemic injury. Oligodendrocyte transcription factor 1 (Olig1) is important for the maturation of OPCs and
Cui Li et al.
Cell discovery, 4, 43-43 (2018-08-08)
The causal link between Zika virus (ZIKV) infection and microcephaly has raised alarm worldwide. Microglial hyperplasia, reactive gliosis, and myelination delay have been reported in ZIKV-infected microcephalic fetuses. However, whether and how ZIKV infection affects glial cell development remain unclear.
Jenna J Boulanger et al.
Frontiers in neuroscience, 11, 143-143 (2017-04-13)
Key Points Oligodendrocyte precursor cells express doublecortin, a microtubule-associated protein.Oligodendrocyte precursor cells express doublecortin, but at a lower level of expression than in neuronal precursor.Doublecortin is not associated with a potential immature neuronal phenotype in Oligodendrocyte precursor cells. Oligodendrocyte precursor

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