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MAB4388

Sigma-Aldrich

Mouse Anti-Stella Antibody

clone 3H5.2, Chemicon®, from mouse

Sinônimo(s):

Anti-Anti-Pgc7, Anti-Anti-STELLA

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

3H5.2, monoclonal

reatividade de espécies

mouse, human

fabricante/nome comercial

Chemicon®

técnica(s)

ELISA: suitable
immunocytochemistry: suitable

entrada

sample type: human embryonic stem cell(s)
sample type induced pluripotent stem cell(s)
sample type: mouse embryonic stem cell(s)

Isotipo

IgG1

nº de adesão NCBI

NM_199286.2

nº de adesão UniProt

Q6W0C5

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

mouse ... Dppa3(73708)

Descrição geral

Stella is specifically expressed by oocytes, pluripotent cells and primordial germ cells at the time of their emergence in gastrulating embryos, and is an important maternal factor in the cleavage stages of mouse embryos (Bortvin, 2004). The requirement for stella in germ cell specification remains controversial, however, most embryos from stella deficient mice failed to develop normally and rarely reach the blastocyst stage (Bortvin, 2004; Payer, 2003). The stella gene encodes a protein with an SAP-like domain and splicing factor motif-like structure, suggesting possible roles in chromosomal organization and RNA processing (Payer, 2003).

Especificidade

Reacts with stella from human and mouse.

Aplicação

Mouse Anti-Stella Antibody detects level of Stella & has been published & validated for use in ELISA & IC.
Research Category
Stem Cell Research
Research Sub Category
Pluripotent & Early Differentiation

forma física

Format: Purified
Purified Immunoglobulin presented as a liquid in PBS with 0.1% sodium azide.

Armazenamento e estabilidade

Maintain refrigerated at 2-8C in undiluted aliquots for up to 12 months.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile.
Sugawa, F; Arauzo-Bravo, MJ; Yoon, J; Kim, KP; Aramaki, S; Wu, G; Stehling, M; Psathaki et al.
The Embo Journal null
Alex Bortvin et al.
BMC developmental biology, 4, 2-2 (2004-03-17)
In mice, germ cells are specified through signalling between layers of cells comprising the primitive embryo. The function of Dppa3 (also known as Pgc7 or stella), a gene expressed in primordial germ cells at the time of their emergence in
Generation of stella-GFP transgenic mice: a novel tool to study germ cell development
Payer, Bernhard, et al
Genesis, 44, 75-83 (2006)
Bernhard Payer et al.
Current biology : CB, 13(23), 2110-2117 (2003-12-05)
stella is a novel gene specifically expressed in primordial germ cells, oocytes, preimplantation embryos, and pluripotent cells. It encodes a protein with a SAP-like domain and a splicing factor motif-like structure, suggesting possible roles in chromosomal organization or RNA processing.
Katja Linher et al.
PloS one, 4(12), e8263-e8263 (2009-12-17)
We have previously demonstrated that stem cells isolated from fetal porcine skin have the potential to form oocyte-like cells (OLCs) in vitro. However, primordial germ cells (PGCs), which must also be specified during the stem cell differentiation to give rise
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