MAB2609

Anti-beta Arrestin 1 Antibody, clone 3H11.2

clone 3H11.2, from mouse

• Sinônimo(s): Retinal S-antigen, Rod photoreceptor arrestin, S-antigen, retina and pineal gland (arrestin), arrestin 1, retinal S-antigen (48 KDa protein)
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: saturated ammonium sulfate (SAS) precipitated
• tipo de produto de anticorpo: primary antibodies
• clone: 3H11.2, monoclonal
• reatividade de espécies: human
• técnica(s): immunofluorescence: suitable; western blot: suitable
• Isotipo: IgMκ
• nº de adesão NCBI: NP_004032.2
• nº de adesão UniProt: P49407
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... ARRB1(408)

Descrição

Descrição geral

The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001).

Especificidade

Other species have not been tested.

Reacts with human beta-arrestin 1.

Imunogênio

Epitope: a.a. 357-372

KLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1.

Aplicação

Anti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.

Research Category
Cell Structure

Research Sub Category
Sensory & PNS

G-proteins

Qualidade

Evaluated on a representative lot by Western blot in HEK293 cell lysate.

Descrição-alvo

~47 kDa

forma física

Format: Purified

Purified in PBS with 0.05% NaN3.

Armazenamento e estabilidade

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Nota de análise

Control
HEK293 cell lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable