ABS518

Anti-SLC5A3 Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): Sodium/myo-inositol cotransporter, Na(+)/myo-inositol cotransporter, Sodium/myo-inositol transporter 1, SMIT1, Solute carrier family 5 member 3
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: human
• técnica(s): immunohistochemistry: suitable (paraffin); western blot: suitable
• nº de adesão NCBI: NP_008864
• nº de adesão UniProt: P53794
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... SLC5A3(6526)

Descrição

Descrição geral

SLC5A3, also known as Sodium/myo-inositol cotransporter, Na (+)/myo-inositol cotransporter, Sodium/myo-inositol transporter 1 (SMT1), or Solute carrier family 5 member 3, and encoded by the gene SLC5A3, is an important intracellular transporter and signaling mediator that mediates the intracellular accumulation of myo-inositol. The compound myo-inositol is important for cell signaling both in the cytoplasm and in intracellular organelles. It is required in the plasma membrane and in the cytoplasm for maintaining the synthesis of the second messengers such as Inositol trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol bisphosphate (PIP2). In organelles myo-inositol is a precursor for the synthesis of complex signaling phospholipids and inositolphosphates from IP3 and PIP2 as well. Moreover, SLC5A3 is upregulated by osmotic shock and downregulated by energy depletion and serves as a molecular sensor of cellular stress.

Imunogênio

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human SLC5A3.

Aplicação

Detect SLC5A3 using this Anti-SLC5A3 Antibody validated for use in western blotting & IHC (Paraffin).

Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected SLC5A3 in human prostate tissues.

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SLC5A3 in human placenta tissues.

Qualidade

Evaluated by Western Blotting in HUVEC cell lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected SLC5A3 in 10 μg of HUVEC cell lysate.

Descrição-alvo

~79 kDa observed

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable