06-756
Anti-Frizzled 5 Antibody
Upstate®, from rabbit
Sinônimo(s):
Fz5, Fzd5
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
reatividade de espécies
rat, human, mouse
fabricante/nome comercial
Upstate®
técnica(s)
western blot: suitable
Isotipo
IgG
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... FZD5(7855)
Descrição geral
The Wnt family consists of ligands involved in cell fate determination, organogenesis, and oncogenesis. The Wnt signal is thought to be transduced sequentially via a homolog of the frizzled family of receptors to GSK-3 (disheveled), β- and γ- catenin and finally to members of the Tcf/Lef-1 family of HMG box transcription factors. Frizzled 5 is believed to function as the receptor for the Wnt5a ligand.
Especificidade
Frizzled 5 (aka Fz5 or Fzd5)
Imunogênio
Epitope: C-Terminus
KLH-conjugated, synthetic peptide derived from amino acids 564-585 of human Frizzled 5 (CTGRTPPGPAATYHKQVSLSHV).
Aplicação
Anti-Frizzled 5 Antibody is an antibody against Frizzled 5 for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
Developmental Signaling
GPCR, cAMP/cGMP & Calcium Signaling
Developmental Signaling
GPCR, cAMP/cGMP & Calcium Signaling
Qualidade
Routinely evaluated by immunoblot on lysates from mouse liver, C2C12, Jurkat or HUVEC cells
Descrição-alvo
Frizzled 5 (62kDa)
forma física
Format: Purified
Protein A chromatography
Purified antibody in PBS with 0.05% sodium azide and 30% Glycerol
Armazenamento e estabilidade
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Nota de análise
Control
Lysates from mouse liver, C2C12, Jurkat, and HUVEC
Lysates from mouse liver, C2C12, Jurkat, and HUVEC
Informações legais
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.
Michaela Bc Kilander,Jacomijn P Dijksterhuis,Ranjani Sri Ganji,Vitezslav Bryja,Gunnar Schulte
Cellular Signalling null
Wnt-frizzled signaling in the induction and differentiation of the neural crest.
Yanfeng, Wang, et al.
Bioessays, 25, 317-325 (2003)
The Frizzled family: receptors for multiple signal transduction pathways.
Huang, Hui-Chuan and Klein, Peter S
Genome Biology, 5, 234-234 (2004)
Y Wang et al.
The Journal of biological chemistry, 271(8), 4468-4476 (1996-02-23)
In Drosophila melanogaster, the frizzled gene plays an essential role in the development of tissue polarity as assessed by the orientation of cuticular structures. Through a combination of random cDNA sequencing, degenerate polymerase chain reaction amplification, and low stringency hybridization
A Bafico et al.
The Journal of biological chemistry, 274(23), 16180-16187 (1999-05-29)
Frizzled related proteins (FRPs) comprise a family of secreted molecules that contain an N-terminal cysteine-rich domain (CRD) highly similar to the CRDs of the frizzled family of membrane-anchored Wnt receptors. FRPs have been shown to interact with Wnt proteins and
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