ABC10
Anti-Megf10 Antibody
from rabbit, purified by affinity chromatography
Sinônimo(s):
Multiple epidermal growth factor-like domains protein 10, Multiple EGF-like domains protein 10
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
purificado por
affinity chromatography
reatividade de espécies
mouse
técnica(s)
immunofluorescence: suitable
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
mouse ... Megf10(70417)
Descrição geral
Multiple epidermal growth factor-like domains protein 10 (Megf10) is a type 1 transmembrane protein with multiple EGF-like extracellular domains. Megf10 is highly expressed in the brain, and plays an important role in phacocytosis of apoptotic cells. This role may be performed through the interaction of Megf10 with the ATP-binding cassette transporter (ABCA1) protein. Previous studies have suggested that Megf10 may be involved in the uptake of amyloid β peptides in the brain. Megf10 may therefore play a role Alzheimer’s disease.
Especificidade
Other homologies: Rat (98% sequence homology) and Human (92% sequence homology).
This antibody recognizes Megf10 at the cytoplasmic domain.
Imunogênio
Epitope: Cytoplasmic domain
Histidine-tagged recombinant protein corresponding to the cytoplasmic domain of mouse Megf10.
Aplicação
Detect the Megf10 protein using this Anti-Megf10 validated for use in WB & IF.
Immunofluorescence Analysis: A representative lot was used by an independent laboratory in P7 caudal brain tissue and retina cells. Image courtesy from the laboratory of Dr. Joshua Sanes, Harvard University.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Qualidade
Evaluated by Western Blot in mouse retina tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Megf10 on 10 µg of mouse retina tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Megf10 on 10 µg of mouse retina tissue lysate.
Descrição-alvo
~130 kDa observed
forma física
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Armazenamento e estabilidade
Stable for 1 year at 2-8°C from date of receipt.
Nota de análise
Control
Mouse retina tissue lysate
Mouse retina tissue lysate
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Dai Shi et al.
International journal of molecular sciences, 24(2) (2023-01-22)
It has been hypothesised that inhalational anaesthetics such as isoflurane (Iso) may trigger the pathogenesis of Alzheimer's disease (AD), while the gaseous anaesthetic xenon (Xe) exhibits many features of a putative neuroprotective agent. Loss of synapses is regarded as one
Hiroyuki Konishi et al.
The EMBO journal, 39(22), e104464-e104464 (2020-09-23)
Microglia are the principal phagocytes that clear cell debris in the central nervous system (CNS). This raises the question, which cells remove cell debris when microglial phagocytic activity is impaired. We addressed this question using Siglechdtr mice, which enable highly
Yin-Peng Chen et al.
Frontiers in molecular neuroscience, 9, 105-105 (2016-11-09)
Cytoplasmic polyadenylation element binding protein 3 (CPEB3) regulates target RNA translation in neurons. Here, we examined CPEB3 distribution and function in the mouse retina. CPEB3 is expressed in retinal neurons, including those located in the inner nuclear layer (INL) and
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