AB5482
Anti-Superoxide Dismutase 1 Antibody
serum, Chemicon®
Sinônimo(s):
SOD1
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
serum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
reatividade de espécies
rat, mouse
não deve reagir com
human
fabricante/nome comercial
Chemicon®
técnica(s)
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... SOD1(6647)
Descrição geral
Mutations in the copper/ zinc superoxide dismutase (SOD1) gene are associated with 15- 20% of the familial forms of motoneuron disease. This 153 amino acid metalloenzyme is expressed in virtually all cells of all organisms above bacteria and is highly conserved across species, although some minor variations do occur. The incorporation of the mutated form of the SOD1 human gene into a transgenic mouse leads to the onset of the disease that closely resembles the human condition. These animals become weak at about 2-4 months of age and rapidly lose function, which results in death 4- 6 weeks later.
Especificidade
Superoxide Dismutase 1 (SOD1), mouse and rat specific. No reactivity with human SOD1
Imunogênio
Synthetic peptide corresponding to amino acids 25-37 of mouse SOD1.
Aplicação
Detect Superoxide Dismutase 1 using this Anti-Superoxide Dismutase 1 Antibody validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Oxidative Stress
Oxidative Stress
Western blotting: 1:200-1:500 (see images)
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
forma física
Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile water.
Armazenamento e estabilidade
Maintain lyophilized material at -70°C (dry) for up to 12 months after date of receipt. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.
Raoul, C; Abbas-Terki, T; Bensadoun, JC; Guillot, S; Haase, G; Szulc, J; Henderson, CE; Aebischer, P
Nature Medicine null
Nerve terminal degeneration is independent of muscle fiber genotype in SOD1 mice.
Carrasco, DI; Bichler, EK; Seburn, KL; Pinter, MJ
Testing null
S E Bartlett et al.
Journal of neuroscience methods, 98(1), 63-67 (2000-06-06)
Mutations in the copper/zinc superoxide dismutase (SOD1) gene are associated with 15-20% of the familial forms of motor neuron disease. Mice where a transgene has been incorporated that encodes for the human SOD1 mutation develop a form of motor neurone
Qian Wang et al.
PloS one, 7(5), e36818-e36818 (2012-05-19)
Hepatitis B virus (HBV) is a major etiological factor of hepatocellular carcinoma (HCC). However, the precise pathogenetic mechanisms linking HBV infection and HCC remain uncertain. It has been reported that decreased antioxidant enzyme activities are associated with severe liver injury
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