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Documentos Principais

AB2204

Sigma-Aldrich

Anti-BMAL1 Antibody

serum, from guinea pig

Sinônimo(s):

ARNT-like protein 1, brain and muscle, Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, member of PAS protein 3, aryl hydrocarbon receptor nuclear translocator-like, bHLH-PAS protein JAP3, basic-helix-loop-helix-PAS orphan MOP3 2, m

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

guinea pig

Nível de qualidade

100

forma do anticorpo

serum

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

mouse, human, rat

técnica(s)

western blot: suitable

nº de adesão NCBI

NP_031515

nº de adesão UniProt

O00327

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ARNTL(406)
mouse ... Arntl(11865)
rat ... Arntl(29657)

Descrição geral

Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock.

Especificidade

Cat. # AB2204 will recognize the C-terminus of BMAL1.
Reactivity with other species has not been tested.

Imunogênio

Epitope: C-Terminus
Recombinant Protein

Aplicação

Anti-BMAL1 Antibody is an antibody against BMAL1 for use in WB.
Research Category
Neuroscience
Research Sub Category
Circadian Rhythm & Sleep

Qualidade

Routinely tested on C2C12 tissue lysate
Lot Specific Tested Application 1: Western Blot

Descrição-alvo

~69 kDa

forma física

Serum with 0.05% NaN3

Armazenamento e estabilidade

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Nota de análise

Control
C2C12 Tissue lysate

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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M K Bunger et al.
Cell, 103(7), 1009-1017 (2001-02-13)
Circadian oscillations in mammalian physiology and behavior are regulated by an endogenous biological clock. Here we show that loss of the PAS protein MOP3 (also known as BMAL1) in mice results in immediate and complete loss of circadian rhythmicity in
Rapid resetting of the mammalian circadian clock.
Best, J D, et al.
The Journal of Neuroscience, 19, 828-835 (1999)
Karen J Tonsfeldt et al.
Journal of the Endocrine Society, 3(4), 716-733 (2019-03-25)
In rodents, the preovulatory LH surge is temporally gated, but the timing cue is unknown. Estrogen primes neurons in the anteroventral periventricular nucleus (AVPV) to secrete kisspeptin, which potently activates GnRH neurons to release GnRH, eliciting a surge of LH
Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus.
LeSauter, J; Lambert, CM; Robotham, MR; Model, Z; Silver, R; Weaver, DR
Testing null
Yohei Kobayashi et al.
Neuron, 86(1), 264-275 (2015-03-25)
Circadian rhythms control a variety of physiological processes, but whether they may also time brain development remains largely unknown. Here, we show that circadian clock genes control the onset of critical period plasticity in the neocortex. Within visual cortex of

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