AB2202
Anti-PER2 Antibody
serum, Chemicon®
Sinônimo(s):
Anti-FASPS, Anti-FASPS1
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
serum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
reatividade de espécies
mouse, rat
fabricante/nome comercial
Chemicon®
técnica(s)
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
mouse ... Per2(18627)
Descrição geral
PER2 is a component of the circadian clock mechanism which is essential for generating circadian rhythms. It is a negative element in the circadian transcriptional loop by Influencing clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. PER2 negatively regulates CLOCK NPAS2-BMAL1 BMAL2-induced transactivation. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
Especificidade
Cat. # AB2202 will recognize the N-terminus of PER2.
Reactivity with other species has not been determined.
Imunogênio
Synthetic peptide.
Aplicação
Anti-PER2 Antibody detects level of PER2 & has been published & validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Circadian Rhythm & Sleep
Circadian Rhythm & Sleep
Western Blot Analysis:
C2C12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PER2 (1:500 dilution of this lot). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
C2C12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PER2 (1:500 dilution of this lot). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
Qualidade
Routinely evaluated by western blot on C2C12 lysate.
Descrição-alvo
Approx. 136 kDa Band may be observed at a much higher 200 kDa by the liver product depending on level of phophorylation and gel system used.
forma física
Serum with 0.05% NaN3
Armazenamento e estabilidade
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
Nota de análise
Control
C2C12 tissue lysate.
C2C12 tissue lysate.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Peiyuan Qiu et al.
National science review, 6(1), 87-100 (2019-01-01)
Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey
Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body.
Evans, JA; Suen, TC; Callif, BL; Mitchell, AS; Castanon-Cervantes, O; Baker, KM; Kloehn et al.
BMC Biology null
Jianwei Wang et al.
Nature cell biology, 21(6), 791-792 (2019-02-28)
In the version of this Article originally published, the authors mistakenly used the same images for the Fig. 2d Per-/- upper Merge, DAPI and p-RPA2 (Ser33), and Fig. 3e upper 2 months, WT Per2 DAPI and Merge panels. The correct
Lamis Saad et al.
Genes, 12(8) (2021-08-28)
The circadian system interacts with the mesocorticolimbic reward system to modulate reward and memory in a time-of-day dependent manner. The circadian discrimination of reward, however, remains difficult to address between natural reinforcers and drugs of abuse. Circadian rhythms control cocaine
Youli Yao et al.
Frontiers in pharmacology, 11, 355-355 (2020-04-10)
Sirtuin 1 (SIRT1) is a protein deacetylase with important cellular functions, as it regulates numerous processes, including the circadian rhythm in peripheral tissues. Efforts are ongoing to reveal how Sirt1 can be used to treat diseases, such as alcoholic liver
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