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Key Documents

AB10140

Sigma-Aldrich

Anti-Drebrin A/E Antibody

from rabbit, purified by affinity chromatography

Sinônimo(s):

Developmentally-regulated brain protein, drebrin 1, drebrin E, drebrin E2

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

purificado por

affinity chromatography

reatividade de espécies

rat, human, mouse

técnica(s)

immunocytochemistry: suitable
western blot: suitable

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... DBN1(1627)

Descrição geral

The developmentally-regulated neuron-specific protein, Drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals were observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast

Especificidade

Cat. # AB10140 detects the internal domain of Drebrin A/E.
May react with human based on sequence homology. Reactivity with other species has not been determined.

Imunogênio

Epitope: Internal Domain
KLH conjugated synthetic linear peptide.

Aplicação

Detect Drebrin A/E using this Anti-Drebrin A/E Antibody validated for use in WB & IC.
Immunocytochemistry: Proven to react with Drebrin A/E in 16 DIV rat cortical neurons. Photo courtesy of Dr. Gang Lui, Drexel University.
Research Category
Neuroscience
Research Sub Category
Synapse & Synaptic Biology

Qualidade

Western Blot:
A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate.

Descrição-alvo

~77 kDa

forma física

Antigen Affinity Purified
Purified rabbit polyclonal antibody in PBS with 0.05% NaN3.

Armazenamento e estabilidade

Stable for 1 year at 2-8ºC from date of receipt.

Nota de análise

Control
Embryonic rat brain (day 16) tissue lysate.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline.
Heather D VanGuilder,Julie A Farley,Han Yan,Colleen A Van Kirk,Matthew Mitschelen et al.
Neurobiology of Disease null
F Ciaffardini et al.
Cell death & disease, 5, e1268-e1268 (2014-05-31)
Cockayne syndrome (CS) is a progressive developmental and neurodegenerative disorder resulting in premature death at childhood and cells derived from CS patients display DNA repair and transcriptional defects. CS is caused by mutations in csa and csb genes, and patients
Kelsie Mozzoni LaBarbera et al.
Journal of neuroscience methods, 358, 109180-109180 (2021-04-10)
Mature primary neuronal cultures are an important model of the nervous system, but limited scalability has been a major challenge in their use for drug discovery of neurodegenerative diseases. This work describes a method for improving scalability through the use

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