8.52105

Fmoc-Arg(Me,Pbf)-OH

Novabiochem^®

• Sinônimo(s): Fmoc-Arg(Me,Pbf)-OH, N-α-Fmoc-N-ω-methyl-N-ωÆ-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine
• Fórmula empírica (Notação de Hill): C₃₅H₄₂N₄O₇S
• Número CAS: 1135616-49-7
• Peso molecular: 662.80
• Número MDL: MFCD08064312
• Código UNSPSC: 12352209
• NACRES: NA.22

Propriedades

• Nível de qualidade: 200
• linha de produto: Novabiochem^®
• Ensaio: ≥95.0% (HPLC)
• Formulário: powder
• adequação da reação: reaction type: Fmoc solid-phase peptide synthesis
• fabricante/nome comercial: Novabiochem^®
• aplicação(ões): peptide synthesis
• grupo funcional: Fmoc
• temperatura de armazenamento: 15-25°C
• cadeia de caracteres SMILES: [S](=O)(=O)(N\C(=N\C)\NCCC[C@H](NC(=O)OCC3c4c(cccc4)c5c3cccc5)C(=O)O)c1c(c2c(c(c1C)C)OC(C2)(C)C)C
• InChI: 1S/C35H42N4O7S/c1-20-21(2)31(22(3)27-18-35(4,5)46-30(20)27)47(43,44)39-33(36-6)37-17-11-16-29(32(40)41)38-34(42)45-19-28-25-14-9-7-12-23(25)24-13-8-10-15-26(24)28/h7-10,12-15,28-29H,11,16-19H2,1-6H3,(H,38,42)(H,40,41)(H2,36,37,39)/t29-/m0/s1
• chave InChI: JAUPJPAADXVUGQ-LJAQVGFWSA-N

Descrição

Descrição geral

A derivative for the introduction of mono-methyl-arginine during Fmoc SPPS. Coupling can be carried out using any standard activation method. Removal of the Pbf protecting group occurs during the course of the TFA-mediated cleavage reaction. Ref ^[1] contains methods and protocols for the synthesis of arrays of histone-related peptides containing methylated arginine and lysine-residues.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] S. Rothbart, et al. (2012) Methods Enzymol., 512, 107.

Ligação

Replaces: 04-12-1261

Nota de análise

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (DC (018A)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informações legais

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable