8.51013

HATU

for peptide synthesis, Novabiochem^®

• Sinônimo(s): HATU, 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide
• Fórmula empírica (Notação de Hill): C₁₀H₁₅N₆O · F₆P
• Número CAS: 148893-10-1
• Peso molecular: 380.23
• Número MDL: MFCD27957364
• Código UNSPSC: 12352107
• NACRES: NA.22

Propriedades

• product name: HATU, Novabiochem^®
• Nível de qualidade: 300
• linha de produto: Novabiochem^®
• forma: solid
• adequação da reação: reaction type: Coupling Reactions
• fabricante/nome comercial: Novabiochem^®
• pf: 186 °C (decomposes)
• aplicação(ões): peptide synthesis
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C10H15N6O/c1-14(2)10(15(3)4)17-16-9-8(12-13-16)6-5-7-11-9/h5-7H,1-4H3/q+1
• chave InChI: WXIONIWNXBAHRU-UHFFFAOYSA-N

Descrição

Descrição geral

A highly efficient coupling reagent for solid and solution phase peptide synthesis. In comparative studies HATU has been found to give better coupling yields with less enantiomerization that HBTU, TBTU or PyBOP^®[1,2,3]. It is particularly effective at coupling to N-alkyl amines where other coupling reagents give poor yields and is the preferred reagent for loading resins bearing secondary amino groups.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] L. A. Carpino (1993) J. Am. Chem. Soc., 115, 4397.
^[2] F. Albericio, et al. (1998) J. Org. Chem., 63, 9678.
^[3] J. A. Carpino, et al., in "Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium", R. Epton (Ed.), Mayflower Worldwide Ltd., 1994, pp. 95.

Ligação

Replaces: 01-62-0041

Nota de análise

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Identity (NMR, 1H): passes test
Solubility (1 mmole in 2 ml DMF): clearly soluble

Informações legais

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H317 - H334
• Declarações de precaução: P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
• Classificações de perigo: Resp. Sens. 1 - Skin Sens. 1
• Código de classe de armazenamento: 4.1A - Other explosive hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable