645900

Triptolide, Tripterygium wilfordii

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

• Sinônimo(s): Triptolide, Tripterygium wilfordii, PG490
• Fórmula empírica (Notação de Hill): C₂₀H₂₄O₆
• Número CAS: 38748-32-2
• Peso molecular: 360.40
• Número MDL: MFCD00210565
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: off-white
• solubilidade: DMSO: 20 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• InChI: 1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
• chave InChI: DFBIRQPKNDILPW-CIVMWXNOSA-N

Descrição

Descrição geral

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Activate DEVD-cleaving caspases

Product does not compete with ATP.

Reversible: no

Embalagem

Packaged under inert gas

Advertência

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Outras notas

Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology40, 139.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H300 + H330,H361f
• Declarações de precaução: P202 - P260 - P264 - P271 - P280 - P304 + P340 + P310
• Classificações de perigo: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable