575310

T0901317

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXRα).

• Sinônimo(s): T0901317, TO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide
• Fórmula empírica (Notação de Hill): C₁₇H₁₂F₉NO₃S
• Número CAS: 293754-55-9
• Peso molecular: 481.33
• Número MDL: MFCD03412028
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: light beige
• solubilidade: DMSO: 50 mg/mL; ethanol: 50 mg/mL
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• InChI: 1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
• chave InChI: SGIWFELWJPNFDH-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXR_α). Reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride in mice. Also reduces the development of atherosclerosis in LDL receptor-deficient mice and lowers plasma glucose in diabetic rodents.

Ações bioquímicas/fisiológicas

Cell permeable: yes

EC50 = 20 nM for LXRα

Primary Target
Liver X receptor (LXRα)

Product does not compete with ATP.

Reversible: no

Embalagem

Packaged under inert gas

Advertência

Toxicity: Harmful (C)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Terasaka, N., et al. 2003. FEBS Lett.536, 6.
Cao, G., et al. 2002. J. Biol. Chem.278, 1131.
Field, F.J., et al. 2002. Biochem. J.368, 855.
Fukumoto, H., et al. 2002. J. Biol. Chem.277, 48508.
DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA98, 1477.
Repa, J.J., et al. 2000. Science289, 1524.
Schultz, J.R., et al. 2000. Genes Dev.14, 2831.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable