567310-M

SKF-96365, Hydrochloride

Inhibits receptor-mediated Ca²⁺ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca²⁺ release.

• Sinônimo(s): SKF-96365, Hydrochloride, 1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl
• Fórmula empírica (Notação de Hill): C₂₂H₂₆N₂O₃ · xHCl
• Número CAS: 130495-35-1
• Peso molecular: 366.45 (free base basis)
• Número MDL: MFCD00236407
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (TLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: white
• solubilidade: water: 2 mg/mL
• temperatura de armazenamento: 10-30°C
• InChI: 1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
• chave InChI: FWLPKVQUECFKSW-UHFFFAOYSA-N

Descrição

Descrição geral

Inhibits receptor-mediated Ca²⁺ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca²⁺ release. Also inhibits voltage-gated Ca²⁺ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Inhibits receptor-mediated Ca²⁺ entry in stimulated platelets (IC₅₀ = 8-12 µM in intact platelets), neutrophils, and endothelial cells (IC₅₀ = 30 µM for human endothelial cells) at concentrations that do not affect internal Ca²⁺ release. Also inhibits voltage-gated Ca²⁺ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Ações bioquímicas/fisiológicas

Primary Target
Inhibits receptor-mediated Ca2+ entry

Advertência

Toxicity: Irritant (B)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Leung, Y.-M., et al. 1996. Biochem. Pharmacol.51, 605.
Schwartz, G., et al. 1994. Cell Calcium15, 45.
Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357.
Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539.
Blayney, L.M., et al. 1991. Biochem. J. 273, 803.
Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351.
Merritt, J.E., et al. 1990. Biochem. J.271, 515.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable