559418

SBHA

A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties.

• Sinônimo(s): SBHA, Suberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII
• Fórmula empírica (Notação de Hill): C₈H₁₆N₂O₄
• Número CAS: 38937-66-5
• Peso molecular: 204.22
• Número MDL: MFCD00192455
• Código UNSPSC: 51111800
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (TLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: white to off-white
• solubilidade: DMSO: 10 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: N(O)C(=O)CCCCCCC(=O)NO
• InChI: 1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
• chave InChI: IDQPVOFTURLJPT-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Reported to cause an increase in acetylated histone H4 in MEL cells. Also reported to inhibit human HDAC1 and HDAC3 activities with a similar potency (ID₅₀ ~ 250-300 nM). Belongs to the hybrid polar class of compounds that induce both differentiation of transformed cells and apoptosis. Shown to suppress the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC₅₀ = 11.57 µM and 5.39 µM, respectively).

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
human HDAC1 and HDAC3 activities

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 11.57 µM and 5.39 µM in suppressing the growth of proliferating keratinocytes and squamous cell carcinoma cells, respectively

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.





From Catalog:

Desc. Field- added "cell-permeable"

Outras notas

Brinkmann, H., et al. 2001. J. Biol. Chem.276, 22491.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 5705.
Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA91, 10251.

Informações legais

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable