5.05823

Galectin-1 Antagonist, DB21

• Sinônimo(s): Galectin-1 Antagonist, DB21, SVQNvaKL-[DBF]-IIVKLNA
• Fórmula empírica (Notação de Hill): C₈₃H₁₃₂N₁₈O₁₇
• Peso molecular: 1654.05
• Código UNSPSC: 12352200

Propriedades

• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• forma: powder
• potência: 3 μM IC₅₀
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: DMSO: 10 mg/mL
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

Ações bioquímicas/fisiológicas

Primary Target
Galectin-1

Reversible: yes

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Sequência

SVQMKNva-[DBF]-IIVKLNA

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable