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459620

Sigma-Aldrich

Okadaic Acid sodium salt

≥98% (TLC), solid,film (colorless), protein phosphatase 2A and protein phosphatase 1 inhibitor, Calbiochem®

Sinônimo(s):

Okadaic Acid, Sodium Salt

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About This Item

Fórmula empírica (Notação de Hill):
C44H67O13 · Na
Peso molecular:
826.98
Código UNSPSC:
12352106
NACRES:
NA.77

Nome do produto

Okadaic Acid, Sodium Salt, Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.

Nível de qualidade

100

Ensaio

≥98% (TLC)

Formulário

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
protect from light

cor

white to off-white

solubilidade

water: 1 mg/mL
DMSO: 20 mg/mL
ethanol: 20 mg/mL

Condições de expedição

ambient

temperatura de armazenamento

−20°C

Descrição geral

Water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.

Ações bioquímicas/fisiológicas

Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 10-15 nM, 0.1 nM against protein phosphatase 1, protein phosphatase 2A, respectively

Advertência

Toxicity: Toxic (F)

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Gjertsen, B.T., et al. 1994. J. Cell Sci.107, 3363.
Kiguchi, K., et al. 1994. Cell Growth Differentiation5, 995.
Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun.197, 916.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun.189, 950.
Kreienbuhl, P., et al. 1992. Blood80, 2911.
Normura, M., et al. 1992. Biochemistry31, 11915.
Song, Q., et al. 1992. J. Cell Physiol.153, 550.
Tada, Y., et al. 1992. Immunopharmacol.24, 17.
Cohen, P., et al. 1990. Trends Biochem. Sci.15, 98.
Cohen, P. 1989. Annu. Rev. Biochem.58, 453.
Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem.254 21435.
Haystead, T.A. et al. 1989. Nature337, 78.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301 + H311 + H331,H315

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Certificados de análise (COA)

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K Kiguchi et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 5(9), 995-1004 (1994-09-01)
To investigate a possible relationship between apoptosis induction and protein phosphorylation in human breast carcinoma cells, we treated three such cell types, MB-231, MCF-7, and AU-565, with okadaic acid (OA), an inhibitor of protein phosphatases 1 and 2A, or phorbol
Q Song et al.
Journal of cellular physiology, 153(3), 550-556 (1992-12-01)
Gamma-radiation, tetrandrine, bistratene A, and cisplatin were all found to induce pronounced morphological changes characteristic of apoptosis and extensive DNA fragmentation in the human BM13674 cell line 8 h after treatment. Apoptosis induced in BM13674 cells by these diverse agents
Protein phosphatases come of age.
P Cohen et al.
The Journal of biological chemistry, 264(36), 21435-21438 (1989-12-25)
Y Tada et al.
Immunopharmacology, 24(1), 17-24 (1992-07-01)
Okadaic acid is a potent tumor promoter and an inhibitor of serine/threonine-specific protein phosphatases. We studied the effect of okadaic acid in human T cell activation and phosphorylation of internal substrates. Okadaic acid at up to 4 nM enhanced phorbol
M Nomura et al.
Biochemistry, 31(47), 11915-11920 (1992-12-01)
Smooth muscle myosin light chain kinase is phosphorylated at two sites (A and B) by different protein kinases. Phosphorylation at site A increases the concentration of Ca2+/calmodulin required for kinase activation. Diphosphorylated myosin light chain kinase was used to determine
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