420101

JAK3 Inhibitor I

The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinônimo(s): JAK3 Inhibitor I, 4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
• Fórmula empírica (Notação de Hill): C₁₆H₁₅N₃O₃
• Número CAS: 202475-60-3
• Peso molecular: 297.31
• Número MDL: MFCD01862614
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white to off-white
• solubilidade: DMSO: 50 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N(c3ccc(cc3)O)c1ncnc2c1cc(c(c2)OC)OC
• InChI: 1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
• chave InChI: HOZUXBLMYUPGPZ-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3) (IC₅₀ = 78 µM). Has no effect on either JAK1, JAK2, Zap/Syk or Src kinases. Blocks thrombin-induced platelet aggregation.

A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC₅₀ = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Janus family kinase 3

Product competes with ATP.

Reversible: yes

Target IC₅₀: 78 µM against Janus family kinase 3

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Outras notas

Tibbles, H.E., et al. 2001. J. Biol. Chem.276, 17815.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res.5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable