401482

IKK-2 Inhibitor V

The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Sinônimo(s): IKK-2 Inhibitor V, N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354
• Fórmula empírica (Notação de Hill): C₁₅H₈ClF₆NO₂
• Número CAS: 978-62-1
• Peso molecular: 383.67
• Número MDL: MFCD00218820
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: ethanol: 1 mg/mL; DMSO: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: FC(F)(F)c1cc(cc(c1)C(F)(F)F)NC(=O)c2c(ccc(c2)Cl)O
• InChI: 1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
• chave InChI: CHILCFMQWMQVAL-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable IKK-2 inhibitor that selectively blocks IκBα phosphorylation (IC₅₀ ~250 nM) and prevents the induction of NF-κB p65 nuclear translocation. Reported to suppress neoplastic proliferation of mast cells with constitutively activated c-kit receptor. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC₅₀<1 µM) in cardiomyocytes, and ameliorate insulin resistance in diabetic KKA_y mice by regulating adiponectin release.

A cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IκBα phosphorylation (IC₅₀ ~ 250 nM) and thereby prevents the induction of NF-κB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC₅₀<1 µM) in cardiomyocytes, and ameliorate insulin resistance in KKA_y mice by regulating adiponectin release.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
IKK-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: ~ 250 nM blocking IκBα phosphorylation

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Kamon, J., et al. 2004. Biochem. Biophys. Res. Commun.323, 242.
Onai, Y., et al. 2004. Cardiovasc. Res.63, 51.
Tanaka, A., et al. 2004. Blood105, 2324.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3