400012

Caspase-1 Inhibitor II

The Caspase-1 Inhibitor II, also referenced under CAS 178603-78-6, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinônimo(s): Caspase-1 Inhibitor II, IL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK
• Fórmula empírica (Notação de Hill): C₂₄H₃₃ClN₄O₈
• Número CAS: 178603-78-6
• Peso molecular: 540.99
• Número MDL: MFCD00237124
• Código UNSPSC: 12352200
• NACRES: NA.54

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated
• cor: white
• solubilidade: DMSO: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• InChI: 1S/C24H33ClN4O8/c1-12(2)21(24(37)26-13(3)22(35)28-17(10-20(33)34)19(32)11-25)29-23(36)18(27-14(4)30)9-15-5-7-16(31)8-6-15/h5-8,12-13,17-18,21,31H,9-11H2,1-4H3,(H,26,37)(H,27,30)(H,28,35)(H,29,36)(H,33,34)/t13-,17-,18-,21-/m0/s1
• chave InChI: UOUBHJRCKHLGFB-DGJUNBOTSA-N

Descrição

Descrição geral

A cell-permeable and irreversible inhibitor of caspase-1 (K_i = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
caspase-1

Product does not compete with ATP.

Reversible: no

Target K_i: 760 pM against caspase-1

Advertência

Toxicity: Standard Handling (A)

Sequência

Ac-Tyr-Val-Ala-Asp-CMK

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Brenner, B., et al. 1998. Cell Death Differ. 5, 29.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841.
Enari, M., et al. 1995. Nature375, 78.
Walker, N.P.C., et al. 1994. Cell78, 343.
Thornberry, N., et al. 1992. Nature356, 768.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable