385880

Hsp25 Kinase Inhibitor

The Hsp25 Kinase Inhibitor controls the biological activity of Hsp25 KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinônimo(s): Hsp25 Kinase Inhibitor, KKKALNRQLGVAA, MK2 Inhibitor, MAPKAP Kinase-2 Inhibitor, MK2 Inhibitor, KKKALNRQLGVAA, MAPKAP Kinase-2 Inhibitor
• Fórmula empírica (Notação de Hill): C₆₁H₁₁₃N₂₁O₁₆
• Peso molecular: 1396.68
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: lyophilized solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white
• solubilidade: DMSO: soluble; water: soluble
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase [also called mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP kinase-2)]. Inhibition is competitive with respect to the substrate peptide (K_i = 8.1 µM) and non-competitive with respect to ATP (K_i = 134 µM).

A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase. Inhibits Hsp25 kinase competitively with respect to the substrate peptide (K_i = 8.1 µM) and non-competitive with respect to ATP (K_i = 134 µM). [Hsp 25 kinase is also called mitogen-activated protein kinase-activated protein kinase-2 (MK2).]

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
(Hsp25) kinase

Product does not compete with ATP.

Reversible: no

Target K_i: 8.1 µM against (Hsp25) kinase

Advertência

Toxicity: Standard Handling (A)

Sequência

H-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH

forma física

Supplied as a trifluoroacetate salt.

Reconstituição

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

Outras notas

Katsoulidis, E., et al. 2005. Cancer Res.65, 9029.
Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable