382110

Histone Acetyltransferase Inhibitor II

The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Sinônimo(s): Histone Acetyltransferase Inhibitor II, 2,6- bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I, 2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I
• Fórmula empírica (Notação de Hill): C₂₀H₁₆Br₂O₃
• Número CAS: 932749-62-7
• Peso molecular: 464.15
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: yellow
• solubilidade: ethanol: 10 mg/mL; DMSO: 25 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C20H16Br2O3/c21-16-10-12(4-6-18(16)23)8-14-2-1-3-15(20(14)25)9-13-5-7-19(24)17(22)11-13/h4-11,23-24H,1-3H2/b14-8+,15-9+
• chave InChI: YOLKEKNTCBWPSD-VOMDNODZSA-N

Descrição

Descrição geral

A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC₅₀ = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC₅₀ ≤ 40 µM) and induce chromatin condensation in HeLa cells.

A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC₅₀ = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC₅₀ ≤40 µM) and induce chromatin condensation in HeLa cells.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.

Outras notas

Costi, R., et al. 2007. J. Med. Chem.50, 1973.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable