266785

Diacylglycerol Kinase Inhibitor I

The Diacylglycerol Kinase Inhibitor I, also referenced under CAS 93076-89-2, controls the biological activity of Diacylglycerol Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinônimo(s): Diacylglycerol Kinase Inhibitor I, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one, R59022, R59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one
• Fórmula empírica (Notação de Hill): C₂₇H₂₆FN₃OS
• Número CAS: 93076-89-2
• Peso molecular: 459.58
• Número MDL: MFCD00055114
• Código UNSPSC: 51111800
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: white
• solubilidade: ethanol: 12 mg/mL; DMSO: 4 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 10-30°C
• cadeia de caracteres SMILES: Fc1ccc(cc1)C(=C3CCN(CC3)CCc4[c]([n]5c([s]cc5)nc4C)=O)c2ccccc2
• InChI: 1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
• chave InChI: MFVJXLPANKSLLD-UHFFFAOYSA-N

Descrição

Descrição geral

Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC₅₀ = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Potentiates this effect in studies of signal-transducing inositol lipid metabolism. Inhibits human platelet DAG kinase in intact cells (IC₅₀ = 3.6 µM) and in isolated membranes (IC₅₀ = 6.7 µM). In porcine thymus cytosol it inhibits the 80 kDa DAG kinase (IC₅₀ = 10 µM) but has no effect on the 150 kDa DAG kinase. Weak dopamine D₂ and histamine H₁ antagonist and strong serotonin-S₂ antagonist.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Diacylglycerol Kinase

Product does not compete with ATP.

Reversible: no

Advertência

Toxicity: Irritant (B)

Reconstituição

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.

Outras notas

Goin, M., et al. 1993. FEBS Lett. 316, 68.
Ohtsuka, T., et al. 1990. J. Biol. Chem.265, 15418.
de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem.260, 15762.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable