217699
RO-3306
≥95% (HPLC), solid, Cdk1 inhibitor, Calbiochem®
Sinônimo(s):
Cdk1 Inhibitor IV, RO-3306
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About This Item
Fórmula empírica (Notação de Hill):
C18H13N3OS2
Peso molecular:
351.45
Código UNSPSC:
12352200
NACRES:
NA.77
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Nome do produto
Cdk1 Inhibitor IV, RO-3306, RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively).
Nível de qualidade
Ensaio
≥95% (HPLC)
Formulário
solid
fabricante/nome comercial
Calbiochem®
condição de armazenamento
OK to freeze
protect from light
cor
brown
solubilidade
DMSO: 10 mg/mL
Condições de expedição
ambient
temperatura de armazenamento
2-8°C
Descrição geral
A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥ 2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. Also available as a 10 mM solution in DMSO (Cat. No. 217721).
Ações bioquímicas/fisiológicas
Cell permeable: yes
Primary Target
Cdk1
Cdk1
Product competes with ATP.
Reversible: no
Target Ki: 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively
Embalagem
Packaged under inert gas
Advertência
Toxicity: Irritant (B)
Reconstituição
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Outras notas
Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA103, 10660.
Informações legais
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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