13-104
MBP (myelin basic protein), bovine, purified
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.41
Produtos recomendados
fonte biológica
bovine
Nível de qualidade
Formulário
liquid
prazo de validade
2 yr
fabricante/nome comercial
Upstate®
técnica(s)
activity assay: suitable
solubilidade
water: soluble
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
bovine ... MBP(618684)
Descrição geral
Myelin basic protein (MBP) belongs to the intrinsically disordered protein family. It is localized in the insulating layer of nerve cells in the brain and spinal cord. It is an abundant protein found in the central nervous system (CNS).
Research area: Cell Signaling
MBP is an alkaline protein with a pI of 11.6, constituting approximately 30% of the total protein content of the myelin in the central nervous system.
MBP is an alkaline protein with a pI of 11.6, constituting approximately 30% of the total protein content of the myelin in the central nervous system.
Aplicação
MBP (myelin basic protein), bovine, purified has been used in western blotting and as a standard in enzyme-linked immunosorbent assay (ELISA).
Ações bioquímicas/fisiológicas
MBP can interact with various polyanionic proteins such as actin, tubulin, Ca2+-calmodulin, and clathrin, as well as negatively charged lipids. Upon binding to these proteins, MBP undergoes structural changes. It is believed to function as a membrane actin-binding protein, potentially enabling its involvement in relaying extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. External signals received by myelin or cultured oligodendrocytes lead to alterations in the phosphorylation of MBP, indicating its participation in signaling. The peptide MBP4-14 is specific for protein kinase C and is resistant to phosphatase activity. Moreover, MBP is extensively utilized in the "in gel" kinase assay, making it a vital biochemical for studying protein kinase activities.
Myelin basic protein (MBP), known as the ‘executive molecule of myelin′, helps in the formation of central nervous system (CNS) myelin. Elevated levels of MBP in the cerebrospinal fluid (CSF) are detected in acute neurological disorders like exacerbating multiple sclerosis, and traumatic brain injury. It is also observed at increased levels during chronic progressive disorders including dementia, tumor cerebri, and metabolic disorders.
Qualidade
routinely evaluated by successfully phosphorylating MAP Kinase 2/Erk2, active (Catalog # 14-173)
forma física
10mM MOPS, pH 7.0, with 0.05% sodium azide
Armazenamento e estabilidade
2 years at -20°C
Outras notas
This product is derived from bovine source. Export of this product to certain countries may be restricted. Please contact Customer Service or your local distributor to inquire about product availability and export options.
Informações legais
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Os clientes também visualizaram
S L Sutor et al.
The Journal of biological chemistry, 274(11), 7002-7010 (1999-03-06)
Cytokines trigger the rapid assembly of multimolecular signaling complexes that direct the activation of downstream protein kinase cascades. Two protein kinases that have been linked to growth factor-regulated proliferation and survival are mitogen-activated protein/ERK kinase (MEK) and its downstream target
Discordant activation of stress-activated protein kinases or c-Jun NH2-terminal protein kinases in tissues of heat-stressed mice
Hu, Y., et al
The Journal of Biological Chemistry, 272, 9113-9119 (1997)
E E Gardiner et al.
The Journal of biological chemistry, 274(17), 11930-11936 (1999-04-17)
The interaction of fibrinogen (Fg) with intercellular adhesion molecule-1 (ICAM) on B-lymphoid Raji cells results in mitogenesis (Gardiner, E. E., and D'Souza, S. E. (1997) J. Biol. Chem. 272, 15474-15480). Incubation of Raji with Fg resulted in the increased tyrosine
A C Maroney et al.
The Journal of biological chemistry, 276(27), 25302-25308 (2001-04-28)
CEP-1347 (KT7515) promotes neuronal survival at dosages that inhibit activation of the c-Jun amino-terminal kinases (JNKs) in primary embryonic cultures and differentiated PC12 cells after trophic withdrawal and in mice treated with 1-methyl-4-phenyl tetrahydropyridine. In an effort to identify molecular
Ras-independent transformation by v-Src.
Aftab, D T, et al.
Proceedings of the National Academy of Sciences of the USA, 94, 3028-3033 (1997)
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica