129876

Amiloride, Hydrochloride

An inhibitor of angiogenesis.

• Sinônimo(s): Amiloride, Hydrochloride, Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
• Fórmula empírica (Notação de Hill): C₆H₈ClN₇O · xHCl
• Número CAS: 2016-88-8
• Peso molecular: 229.63 (free base basis)
• Número MDL: MFCD00058197
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• cor: off-white to yellow
• solubilidade: water: 2.5 mg/mL; DMSO: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 10-30°C
• cadeia de caracteres SMILES: Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl
• InChI: 1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
• chave InChI: ACHKKGDWZVCSNH-UHFFFAOYSA-N

Descrição

Descrição geral

An inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na⁺/H⁺ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.

An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na⁺ entry and Na⁺,K⁺-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
capillary morphogenesis

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 130 µM inhibiting capillary morphogenesis completely and reversibly

Advertência

Toxicity: Toxic (F)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Knoll, A., et al. 1999. Microvasc. Res.58, 1.
Swiercz, R., et al. 1999. Oncol. Rep.6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable