124015

Akt Inhibitor IV

InSolution, ≥98%

• Sinônimo(s): InSolution Akt Inhibitor IV
• Fórmula empírica (Notação de Hill): C₃₁H₂₇IN₄S
• Peso molecular: 614.54
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: liquid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

A cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 625 nM) and cell proliferation (IC₅₀<1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Akt

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 625 nM and <1.25 µM in blocking Akt-mediated FOXO1a nuclear export and cell proliferation, respectively, in 786-O cells

Embalagem

Packaged under inert gas

Please refer to vial label for lot-specific concentration.

Advertência

Toxicity: Irritant (B)

forma física

A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.

Reconstituição

Following initial use, aliquot and refrigerate (4°C).

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Ponto de fulgor (°C): 87 °C - closed cup - (Dimethylsulfoxide)