1.11474

1,4-ditiotreitol

for biochemistry

• Sinônimo(s): 1,4-ditiotreitol, DTT, reagente de Cleland
• Fórmula linear: (C₂H₃OHSH)₂
• Número CAS: 3483-12-3
• Peso molecular: 154.25
• Número MDL: MFCD00004877
• Código UNSPSC: 12352104
• Número do índice EC: 222-468-7

Propriedades

• grau: for biochemistry
• Nível de qualidade: 200
• Ensaio: ≥99% (iodometric)
• forma: solid
• potência: 400 mg/kg LD₅₀, oral (Rat)
• adequação da reação: reagent type: reductant
• pH: 5.1 (20 °C, 10 g/L in H₂O)
• pf: 40-43 °C
• temperatura de transição: flash point >110 °C
• densidade volumétrica: 300 kg/m³
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1
• chave InChI: VHJLVAABSRFDPM-IMJSIDKUSA-N

Descrição

Aplicação

• Drug delivery using reduction-responsive hydrogel based on carboxyethyl-succinoglycan with highly improved rheological, antibacterial, and antioxidant properties.: This study explores the application of 1,4-Dithiothreitol in developing reduction-responsive hydrogels, highlighting significant enhancements in rheological, antibacterial, and antioxidant characteristics, suitable for drug delivery systems (Kim et al., 2024).


• Preparation and properties of hydrogel photonic crystals assembled by biodegradable nanogels.: Research discusses the integration of 1,4-Dithiothreitol in the assembly of hydrogel photonic crystals using biodegradable nanogels, emphasizing their potential in creating novel photonic materials (Zhang et al., 2024).


• Optimized total RNA isolation from bovine sperm with enhanced sperm head lysis.: The paper highlights the use of 1,4-Dithiothreitol in optimizing RNA isolation techniques from bovine sperm, which enhances sperm head lysis, crucial for reproductive biology studies (Tiwari et al., 2024).


• Preparation of a Convertible Spacer Containing a Disulfide Group for Versatile Functionalization of Oligonucleotides.: Discusses the synthesis of a convertible spacer containing a disulfide group using 1,4-Dithiothreitol, enabling versatile functionalization of oligonucleotides for therapeutic and diagnostic applications (Pontarelli et al., 2023).

Nota de análise

Teor (iodométrico): ≥ 99%
Identidade (espectro IV): passa no teste
Ponto de fusão: 40-43 °C
Metais pesados (como Pb): ≤ 10 ppm
Fe (ferro): ≤ 5 ppm

Informações de segurança

• Pictogramas: GHS05,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302 - H315 - H318
• Declarações de precaução: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable