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Documentos Principais

07-2274

Sigma-Aldrich

Anti-FSP1/S100A4 Antibody

from rabbit

Sinônimo(s):

S100 calcium binding protein A4, S100 calcium-binding protein A4, fibroblast-specific protein-1, leukemia multidrug resistance associated protein, S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog), malig

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702

fonte biológica

rabbit

Nível de qualidade

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

mouse, human

técnica(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

Isotipo

IgG

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... S100A4(6275)
mouse ... S100A4(20198)

Descrição geral

Fibroblast-specific protein-1 (FSP1)/S100A4 is a cytoplasmic calcium-binding protein belonging to the S100 superfamily of which at least 21 members have been identified so far. Researchers believe that FSP1/S1004A is highly expressed in fibroblasts (Iwano et al., 2001; Strutz et al., 1995), in epithelial and endothelial cells undergoing epithelial-mesenchymal transition (EMT) (Iwano et al., 2002; Zeisberg and Neilson, 2009), and epithelial cancer cells that complete a transition to a metastatic phenotype (Xue et al., 2003).

Imunogênio

Epitope: Unknown
Histidine-tagged recombinant protein corresponding to mouse FSP1/S100-A4.

Aplicação

Detect the FSP1/S100A4 protein using this Anti-FSP1/S100A4 validated for use in WB & IHC.
Research Category
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
Western Blot Analysis: 1 µg/mL from a previous lot detected S100-A4 on 10 µg of HeLa cell lysate.

Qualidade

Evaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected FSP1/S100-A4 on 10 µg of NIH/3T3 cell lysate.

Descrição-alvo

~ 12 kDa

forma física

Format: Purified
Protein G Purified
Purified rabbit polyclonal containing PBS with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
NIH/3T3 cell lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Renal fibrosis features exaggerated inflammation, extracellular matrix (ECM) deposition, and peritubular capillary loss. We previously showed that IL-10 stimulates high-molecular weight hyaluronan (HMW-HA) expression by fibroblasts, and we hypothesize that HMW-HA attenuates renal fibrosis by reducing inflammation and ECM remodeling.
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