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Key Documents

06-944

Sigma-Aldrich

Anti-TPOR/c-Mpl Antibody

Upstate®, from rabbit

Sinônimo(s):

Anti-C-MPL, Anti-MPLV, Anti-THCYT2, Anti-THPOR, Anti-TPOR

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

purified antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

mouse, human

fabricante/nome comercial

Upstate®

técnica(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG

nº de adesão NCBI

NM_005373

nº de adesão UniProt

P40238

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... MPL(4352)
mouse ... Mpl(17480)

Especificidade

glycosylated and unglycosylated TPO receptor/c-Mpl

Imunogênio

KLH-conjugated, synthetic peptide corresponding to amino acids 615-628 of human TPO (thrombopoietin) receptor (C-ANHSYLPLSYWQQP)

Aplicação

Anti-TPOR/c-Mpl Antibody is an antibody against TPOR/c-Mpl for use in IP, WB, IH.
Research Category
Signaling
Research Sub Category
Growth Factors & Receptors

Qualidade

routinely evaluated by immunoblot on RIPA lysates from DAMI cells

Descrição-alvo

68.5 kDa (calculated)

forma física

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A chromatography

Armazenamento e estabilidade

2 years at -20°C

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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A R Moliterno et al.
Blood, 94(8), 2555-2561 (1999-10-09)
Recently, we demonstrated a marked reduction in the expression of the thrombopoietin receptor, Mpl, in polycythemia vera (PV) platelets and megakaryocytes using an antiserum against the Mpl extracellular domain. To further examine this abnormality, we raised an antibody to the
Cédric Cleyrat et al.
Traffic (Copenhagen, Denmark), 15(9), 961-982 (2014-06-17)
Myeloproliferative neoplasms (MPNs) are often characterized by JAK2 or calreticulin (CALR) mutations, indicating aberrant trafficking in pathogenesis. This study focuses on Mpl trafficking and Jak2 association using two model systems: human erythroleukemia cells (HEL; JAK2V617F) and K562 myeloid leukemia cells
Reiji Nozaki et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 43(6), 610-620 (2012-11-20)
Liver cirrhosis (LC) is the end stage of chronic liver disease. No definitive pharmacological treatment is currently available. We previously reported that thrombopoietin (TPO) promoted liver regeneration and improved liver cirrhosis by increasing platelet count. TPO is therefore considered to
Low or undetectable TPO receptor expression in malignant tissue and cell lines derived from breast, lung, and ovarian tumors.
Erickson-Miller, CL; Pillarisetti, K; Kirchner, J; Figueroa, DJ; Ottesen, L; Martin et al.
BMC Cancer null
Melanie Märklin et al.
Journal of cellular and molecular medicine, 24(21), 12491-12503 (2020-09-22)
Thrombocyte formation from megakaryocyte and their progenitor cells is tightly regulated by thrombopoietin (TPO) and its receptor c-MPL, thereby maintaining physiological functionality and numbers of circulating platelets. In patients, dysfunction of this regulation could cause thrombocytopenia or myeloproliferative syndromes. Since
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