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Merck
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Documentos Principais

05-233

Sigma-Aldrich

Anti-Nitrotyrosine Antibody, clone 1A6

clone 1A6, Upstate®, from mouse

Sinônimo(s):

Anti-nitrotyrosine antibody

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

1A6, monoclonal

reatividade de espécies

vertebrates

fabricante/nome comercial

Upstate®

técnica(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG2bκ

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... NOS1(4842)

Descrição geral

Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Previous studies have shown that nitrotyrosine has been found in inflammatory conditions such as atherosclerotic plaques and rheumatoid arthritis, among others

Aplicação

Anti-Nitrotyrosine Antibody, clone 1A6 detects level of Nitrotyrosine & has been published & validated for use in IC, IH, IP & WB.

Qualidade

routinely evaluated on peroxynitrite-treated A431 cells; no reaction was noted with non-nitrated proteins

Descrição-alvo

Predicted MW for nitrated-BSA: 66 kDa

forma física

Format: Purified
Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in 0.014M phosphate buffer, pH 7.6, 0.175M NaCl, 0.07% sodium azide, and 30% glycerol.

Nota de análise

Control
Immunohistochemistry: Human Alzheimer disease brain sections (Methacarn fixed), mouse liver
Immunoblotting: Nitrated-BSA
Indirect ELISA: nitrated-BSA
Indirect immunofluorescence: A549 cells metabolically labeled with 3-nitrotyrosine

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin II but not N(?)-nitro-L-arginine methyl ester hypertensive rats.
Sasser, JM; Molnar, M; Baylis, C
Hypertension null
Losartan prevents portal hypertension-induced, redox-mediated endothelial dysfunction in the mesenteric artery in rats.
Dal-Ros, Stephanie, et al.
Gastroenterology, 138, 1574-1584 (2010)
Peroxynitrite diminishes myogenic activity and is associated with decreased vascular smooth muscle F-actin in rat posterior cerebral arteries.
Maneen, MJ; Hannah, R; Vitullo, L; DeLance, N; Cipolla, MJ
Stroke null
Biological significance of nitric oxide-mediated protein modifications.
Gow, Andrew J, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 287, L262-L268 (2004)
The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice.
Alkam, T; Nitta, A; Mizoguchi, H; Itoh, A; Murai, R; Nagai, T; Yamada, K; Nabeshima, T
Journal of Pharmacology and Experimental Therapeutics null
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