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850150P

Avanti

18:1 PI(3)P

Avanti Research - A Croda Brand

Sinônimo(s):

PIP[3′](18:1/18:1)

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About This Item

Fórmula empírica (Notação de Hill):
C45H90N2O16P2
Número CAS:
Peso molecular:
977.15
Código UNSPSC:
51191904
NACRES:
NA.25

descrição

1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′-phosphate) (ammonium salt)

Ensaio

>99% (TLC)

forma

powder

embalagem

pkg of 1 × 100 μg (with stopper and crimp cap (850150P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850150P-500ug))

fabricante/nome comercial

Avanti Research - A Croda Brand

tipo de lipídio

cardiolipins
phospholipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+]

Descrição geral

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.
Phosphatidylinositol phosphate is present in the plasma membrane.

Aplicação

18:1 PIP has been used in liposome preparation. It may also be used to generate small unilamellar vesicles for liposome flotation assays.

Ações bioquímicas/fisiológicas

Phosphatidylinositol phosphate helps to promote the plasma membrane H+-ATPase of Saccharomyces cerevisiae. Phosphatidylinositol 3-phosphate (PtdIns3P) is very essential for the biogenesis of autophagosomes and their precursors.

Embalagem

2 mL Amber Serum Vial with Stopper and Crimp Cap (850150P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850150P-500ug)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

geralmente comprado junto com este produto

Nº do produto
Descrição
Preços

Código de classe de armazenamento

11 - Combustible Solids


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Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion
Dolat L and Spiliotis ET
The Journal of Cell Biology, 214(5), 517-527 (2016)
Mariko Yokogawa et al.
The Journal of biological chemistry, 287(42), 34936-34945 (2012-08-24)
Phosphoinositides (PIs) are crucial lipid components of membranes and are involved in a number of cellular processes through interactions with their effector proteins. Recently, we have established a lipid-protein nanoscale bilayer (nanodisc) containing PIs, hereafter referred to as PI-nanodisc and
Richard J Chi et al.
The Journal of cell biology, 204(5), 793-806 (2014-02-26)
Retromer is an endosomal sorting device that orchestrates capture and packaging of cargo into transport carriers coated with sorting nexin BAR domain proteins (SNX-BARs). We report that fission of retromer SNX-BAR-coated tubules from yeast endosomes is promoted by Vps1, a
Phosphatidylinositol phosphate, phosphatidylinositol bisphosphate, and the phosphoinositol sphingolipids are found in the plasma membrane and stimulate the plasma membrane H+-ATPase of Saccharomyces cerevisiae
Patton JL and Lester RL
Archives of Biochemistry and Biophysics, 292(1), 70-76 (1992)
Etienne Morel et al.
Nature communications, 4, 2250-2250 (2013-08-03)
Defects in endosomal sorting have been implicated in Alzheimer's disease. Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide synthesized primarily by lipid kinase Vps34. Here we show that phosphatidylinositol-3-phosphate is selectively deficient in brain tissue from humans with Alzheimer's

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