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Documentos Principais

850144P

Avanti

18:0-20:4 PI

Avanti Research - A Croda Brand

Sinônimo(s):

1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1′-myo-inositol) (ammonium salt); SAPI; PI(18:0/20:4(5Z,8Z,11Z,14Z)); 110661

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About This Item

Fórmula empírica (Notação de Hill):
C47H86NO13P
Número CAS:
Peso molecular:
904.16
Código UNSPSC:
51191904
NACRES:
NA.25

descrição

1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol (ammonium salt)

Ensaio

>99% (TLC)

forma

powder

embalagem

pkg of 1 × 100 μg (with stopper and crimp cap (850144P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850144P-500ug))

fabricante/nome comercial

Avanti Research - A Croda Brand

tipo de lipídio

cardiolipins
phospholipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O[C@H]1[C@@H]([C@H](O)[C@H](O)[C@@H](O)[C@@H]1O)OP(OC[C@H](OC([C19H31])=O)COC(CCCCCCCCCCCCCCCCC)=O)([O-])=O.[NH4+]

Descrição geral

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.

Aplicação

18:0-20:4 PI or 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol (ammonium salt) has been used:
  • as a negative control to evaluate the specificity of the interaction between cholesterol sulfate and receptor Mincle by surface plasmon resonance (SPR) experiment
  • as a test lipid in liposomes harboring candidate triggering receptor expressed on myeloid cells 2 (TREM2) ligands, to assess TREM2 stimulation
  • as a reference in liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis to identify PI(18:0/20:4) in cancer tissue-originated spheroids (CTOSs) extraction

Embalagem

2 mL Amber Serum Vial with Stopper and Crimp Cap (850144P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850144P-500ug)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Accumulating evidence indicates that cancer cells show specific alterations in phospholipid metabolism that contribute to tumour progression in several types of cancer, including colorectal cancer. Questions still remain as to what lipids characterize the outer edge of cancer tissues and
Alicia A Nugent et al.
Neuron, 105(5), 837-854 (2020-01-07)
Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin phagocytosis, but its role in microglial lipid metabolism is unknown. Combining chronic demyelination paradigms and cell sorting with RNA
Jung Yong Eum et al.
Journal of chromatography. A, 460849-460849 (2020-01-14)
Aging refers to the intracellular accumulation of reactive oxygen species that damages proteins, DNA, and lipids. As alterations in lipid metabolism may trigger metabolic disorders and the onset of metabolic diseases, changes in lipid profiles can be closely related to
Annemieke de Jong et al.
Nature immunology, 15(2), 177-185 (2013-12-24)
T cells autoreactive to the antigen-presenting molecule CD1a are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids. After capturing CD1a-lipid complexes, we

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