810602P
Avanti
16:0-7 Doxyl PC
Avanti Research™ - A Croda Brand 810602P, powder
Sinônimo(s):
1-palmitoyl-2-stearoyl-(7-doxyl)-sn-glycero-3-phosphocholine
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About This Item
Fórmula empírica (Notação de Hill):
C46H90N2O10P
Número CAS:
Peso molecular:
862.19
Código UNSPSC:
41141825
NACRES:
NA.25
Produtos recomendados
Ensaio
>99% (TLC)
Formulário
powder
embalagem
pkg of 1 × 1 mg (810602P-1mg)
fabricante/nome comercial
Avanti Research™ - A Croda Brand 810602P
tipo de lipídio
ESR probes
phospholipids
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
Categorias relacionadas
Descrição geral
Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.
Phosphatidylcholine (PC), a strong bilayer-forming lipid is the most common phospholipid in mammalian membranes. Several prokaryotic and eukaryotic pathogens has phosphorylcholine as its structural constituent.
Ações bioquímicas/fisiológicas
Phosphorylcholine (PC) possesses immunomodulatory properties.
Embalagem
5 mL Clear Glass Sealed Ampule (810602P-1mg)
Nota de preparo
Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM , Additional supplemental information.
Informações legais
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Código de classe de armazenamento
11 - Combustible Solids
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W Harnett et al.
Immunology today, 20(3), 125-129 (1999-04-22)
Phosphorylcholine (PC) is a structural component of a variety of prokaryotic and eukaryotic pathogens. In some cases, PC in infectious agents can benefit the infected host due to its targeting by both the innate and adaptive immune responses. However, as
Delivery of nitroxide spin label to cultured cells by liposomes
Chan HC
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 8, 160-170 (1988)
Phosphatidylserine dynamics in cellular membranes.
Kay, J.G
Molecular Biology of the Cell, 23, 2198-2212 (2012)
Insight into antibody combining sites using nuclear magnetic resonance and spin label haptens
McConnell HM
Advances in Protein Chemistry, 49, 135-148 (1996)
Ultra-stable temperature control in EPR experiments: thermodynamics of gel-to-liquid phase transition in spin-labeled phospholipid bilayers and bilayer perturbations by spin labels
Alaouie AM, et. al.
Journal of Magnetic Resonance, 182, 229-238 (2006)
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