700125P
Avanti
DMHCA
Avanti Research™ - A Croda Brand 700125P, powder
Sinônimo(s):
N,N-dimethyl-3β-hydroxycholenamide
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About This Item
Fórmula empírica (Notação de Hill):
C26H43NO2
Número CAS:
Peso molecular:
401.63
Número MDL:
Código UNSPSC:
12352211
NACRES:
NA.25
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Ensaio
>99% (TLC)
Formulário
powder
embalagem
pkg of 1 × 5 mg (700125P-5mg)
fabricante/nome comercial
Avanti Research™ - A Croda Brand 700125P
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
Descrição geral
N,N-dimethyl-3β-hydroxy-cholenamide (DMHCA) is a potent steroidal liver X receptor (LXR) ligand in vitro and in vivo. It is used to treat atherosclerosis.
Aplicação
DMHCA has been used as LXR activator to treat retinal endothelial cells in order to activate the sirtuin 1- liver X receptors (SIRT1-LXR) pathway.
It may be used as 3β-hydroxysterol-Δ24-reductase (DHCR24) inhibitor.
Ações bioquímicas/fisiológicas
N,N-dimethyl-3β-hydroxycholenamide (DHMCA) halts cholesterol biosynthesis by inhibiting 3β-hydroxysterol-Δ24-reductase (DHCR24) enzyme. It may serve as a therapeutic agent for treating atherosclerosis, age-related macular degeneration and diabetic retinopathy.
DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is a synthetic oxysterol and is an agonist for liver X receptors (LXR). It promotes cholesterol transport, expression of adenosine triphosphate (ATP) binding cassette transporters. DMHCA suppresses the proinflammatory cytokines stimulation, induced by oxysterol.
Embalagem
5 mL Amber Glass Screw Cap Vial (700125P-5mg)
Informações legais
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Código de classe de armazenamento
11 - Combustible Solids
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Certificados de análise (COA)
Lot/Batch Number
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Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor.
Quinet E M, et al.
Journal of Lipid Research, 45(10), 1929-1942 (2004)
The mechanism of diabetic retinopathy pathogenesis unifying key lipid regulators, sirtuin 1 and liver X receptor
Hammer SS, et al.
EBioMedicine, 22, 181-190 (2017)
Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein
Scoles DR, et al.
Gynecologic Oncology, 116(1), 109-116 (2010)
Synthetic LXR agonist attenuates plaque formation in apoE-/-mice without inducing liver steatosis and hypertriglyceridemia
Kratzer A, et al.
Journal of Lipid Research, 50(2), 312-326 (2009)
Nicole El-Darzi et al.
Frontiers in pharmacology, 9, 827-827 (2018-08-10)
N,N-dimethyl-3β-hydroxycholenamide (DMHCA) is an experimental pharmaceutical and a steroidal liver X receptor (LXR) agonist, which does not induce undesired hepatic lipogenesis. Herein, DMHCA was evaluated for its retinal effects on normal C57BL/6J and Cyp27a1-/-Cyp46a1-/- mice; the latter having higher retinal
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