131303P
Avanti
Cerebrosides (Brain)
Avanti Research™ - A Croda Brand
Sinônimo(s):
Total Cerebrosides (Brain, Porcine)
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About This Item
Produtos recomendados
Ensaio
>99% (TLC)
forma
powder
embalagem
pkg of 1 × 25 mg (131303P-25mg)
fabricante/nome comercial
Avanti Research™ - A Croda Brand
tipo de lipídio
sphingolipids
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
Categorias relacionadas
Descrição geral
Cerebrosides are glycosphingolipids with either glucose or galactose as a polar head group. They comprise the major component of the myelin lipids. Cerebrosides are part of non-neural cells including the epithelial cells associated with skin and the digestive system. Cerebrosides are amphipathic in nature.
The total brain cerebrosides appear as a double spot on thin layer chromatography (chloroform/methanol/water, 65:25:4 v/v). The top spot corresponds to ceresine which contain non-hydroxylated fatty acids, and the bottom spot corresponds to phrenosin which contain hydroxylated fatty acids.This Natural Lipid is a mixture and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.
Aplicação
Cerebrosides (Brain) has been used:
- in the coating of coverslips for neurite outgrowth assay of retinal ganglion cells
- in reconstruction of the apical membrane of Madin-Darby canine kidney (MDCK) cells
- in the preparation of liposomes to mimic the MDCK cell membrane for permeability studies
Ações bioquímicas/fisiológicas
Cerebrosides regulate a variety of physiological processes like cell growth, survival and multiplication. They coordinate membrane trafficking and inhibit apoptosis. Inborn metabolic disorder, Gaucher′s disease is associated with elevated levels of cerebrosides.. Additionally, cerebrosides provide structural support to the membranes and mediate intracellular communication. Accumulation of galactocerebrosides is associated with tumors. It also serves as a receptor for human immune deficiency virus (HIV) glycoprotein. The porcine cerebroside and ganglioside (CPCG) is used in treating neurotoxicity induced by the drug oxaliplatin in digestive system tumors.
Embalagem
5 mL Amber Glass Screw Cap Vial (131303P-25mg)
Informações legais
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Código de classe de armazenamento
11 - Combustible Solids
Certificados de análise (COA)
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Direct visualization of the lateral structure of porcine brain cerebrosides/POPC mixtures in presence and absence of cholesterol
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Biophysical Journal, 97(1), 142-154 (2009)
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