930083

2-(Pyrimidin-5-yl)phenol

≥95%

• Sinônimo(s): Maiti-Bag-Dutta Auxiliary
• Fórmula empírica (Notação de Hill): C₁₀H₈N₂O
• Número CAS: 18313-50-3
• Peso molecular: 172.18
• Número MDL: MFCD06802618
• Código UNSPSC: 12352100
• NACRES: NA.21

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95%
• forma: powder
• pf: 173 °C
• temperatura de armazenamento: −20°C

Descrição

Aplicação

2-(Pyrimidin-5-yl)phenol is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-Fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.

2-(Pyrimidin-5-yl)phenol is an effective TDG for meta directed C-H functionalization of substitutes with a variety of electron withdrawing functional groups, with high selectivity.

Outras notas

Arene diversification through distal C(sp2)−H functionalization
Palladium-Catalyzed meta-C–H Allylation of Arenes: A Unique Combination of a Pyrimidine-Based Template and Hexafluoroisopropanol

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable