930075

2-fluoro-6-(pyrimidin-5-yl)aniline

≥95%

• Fórmula empírica (Notação de Hill): C₁₀H₈FN₃
• Número CAS: 1697040-97-3
• Peso molecular: 189.19
• Código UNSPSC: 12352106

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95%
• forma: powder, crystals or chunks
• cor: light yellow
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: NC1=C(C2=CN=CN=C2)C=CC=C1F

Descrição

Aplicação

2-fluoro-6-(pyrimidin-5-yl)aniline is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.


2-fluoro-6-(pyrimidin-5-yl)aniline is an effective TDG for meta directed C-H functionalization of aldehyde substituted target compounds, with high selectivity.

Outras notas

1. Imine as a linchpin approach for meta-C–H functionalization2. Transient directing ligands for selective metal-catalysed C–H activation

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable