91862

Trimethyl(trifluoromethyl)silane solution

2 M in THF

• Sinônimo(s): (Trifluoromethyl)trimethylsilane, Ruppert′s reagent, Ruppert-Prakash reagent, TFMTMS, Trifluoromethyltrimethylsilane
• Fórmula linear: (CH₃)₃SiCF₃
• Número CAS: 81290-20-2
• Peso molecular: 142.19
• Beilstein: 4241868
• Número MDL: MFCD00145454
• Código UNSPSC: 12352101
• ID de substância PubChem: 57653455
• NACRES: NA.22

Propriedades

• forma: liquid
• Nível de qualidade: 100
• adequação da reação: reaction type: C-C Bond Formation
• IVD: for in vitro diagnostic use
• concentração: 2 M in THF
• índice de refração: n20/D 1.386
• densidade: 0.91 g/mL at 20 °C
• cadeia de caracteres SMILES: C[Si](C)(C)C(F)(F)F
• InChI: 1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
• chave InChI: MWKJTNBSKNUMFN-UHFFFAOYSA-N

Descrição

Descrição geral

Trimethyl(trifluoromethyl)silane (TMSCF₃) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.

Aplicação

Reactant for:

• Silver-mediated C-H trifluoromethylation of arenes
• Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
• Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
• Palladium-catalyzed oxidative trifluoromethylation of indoles
• Preparation of 5-HT1A antagonists

• Used as difluorocarbene source

TMSCF₃ can be used as a reagent for:

• Conversion of aromatic aldehydes to difluoromethylated products.
• C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction.

It can also be used in trifluoromethylation of:

• Non-activated aldimines.
• Heterocumulenes.
• Azomethine imines.

Informações de segurança

• Pictogramas: GHS02,GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H225,H302,H319,H335,H351
• Declarações de precaução: P210 - P280 - P301 + P312 + P330 - P305 + P351 + P338 - P370 + P378 - P403 + P235
• Classificações de perigo: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Perigos de suplementos: EUH019
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 1.4 °F
• Ponto de fulgor (°C): -17 °C
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter