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901702

Sigma-Aldrich

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average Mn 5000, PCL average Mn 5000

Sinônimo(s):

Carboxylic acid PEG-PCL diblock copolymer, Carboxylic acid-PEG-PCL, PEG-b-PCL, PEG-PCL

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About This Item

Fórmula linear:
C6H11O3S[C2H4O]n[C6H10O2]mH
Código UNSPSC:
12352106
NACRES:
NA.23

Formulário

powder or solid

peso molecular

PCL average Mn 5000
PEG average Mn 5000

cor

white to off-white

PDI

≤1.3 (by GPC)

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

Aplicação

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
MKCG5257

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Jian Jin et al.
PloS one, 9(11), e112200-e112200 (2014-11-12)
In this content, a small molecular ligand of prostate specific membrane antigen (SMLP) conjugated poly (caprolactone) (PCL)-b-poly (ethylene glycol) (PEG) copolymers with different block lengths were synthesized to construct a satisfactory drug delivery system. Four different docetaxel-loaded polymeric micelles (DTX-PMs)
Cem Varan et al.
Beilstein journal of nanotechnology, 8, 1446-1456 (2017-09-14)
Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development

Artigos

Microfluidic-Assisted Manufacturing of Materials for Nanomedicine

Professor Nicola Tirelli (Istituto Italiano di Tecnologia, Italy) highlights the microfluidic-assisted method for fabricating well-defined and reproducible nanoparticles for drug delivery research.

Microfluidic-Assisted Manufacturing of Materials for Nanomedicine

Professor Nicola Tirelli (Istituto Italiano di Tecnologia, Italy) highlights the microfluidic-assisted method for fabricating well-defined and reproducible nanoparticles for drug delivery research.

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