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79380

Sigma-Aldrich

Phosgene solution

~20% in toluene

Sinônimo(s):

Carbon oxychloride, Carbonyl chloride, Phosgen

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About This Item

Fórmula linear:
COCl2
Número CAS:
75-44-5
Peso molecular:
98.92
Beilstein:
1098367
Número MDL:
MFCD00036119
Código UNSPSC:
12352101
ID de substância PubChem:
57652789
NACRES:
NA.22

forma

solution

Nível de qualidade

200

adequação da reação

reaction type: Carbonylations

concentração

~20% in toluene

Impurezas

≤300 mg/kg benzene

grupo funcional

chloro

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

ClC(Cl)=O

InChI

1S/CCl2O/c2-1(3)4

chave InChI

YGYAWVDWMABLBF-UHFFFAOYSA-N

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Descrição geral

Phosgene is an organic chemical compound widely used as a chlorinating agent, carbonylating agent, and dehydrating agent in organic synthesis for the synthesis of various compounds.

Aplicação

Phosgene solution (~20% in toluene) can be used as a reagent in the synthesis of multiblock copolymers via multiple coupling reactions. It is also used in the activation of the hydroxyl groups in poly(ethylene glycol) diol (PEG diol) to synthesize linear multifunctional poly(ethylene glycol).

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 2 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT SE 1 Inhalation - STOT SE 3

Órgãos-alvo

Central nervous system, Lungs

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

39.2 °F - closed cup

Ponto de fulgor (°C)

4 °C - closed cup

Equipamento de proteção individual

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
BCCH0727
BCCD0152
BCCB1850
BCBW6315
BCBG3952

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Pradip Kundu et al.
Analytical chemistry, 84(10), 4594-4597 (2012-04-11)
Phosgene is a very toxic gas, which was used as a chemical weapon in World War I, and is currently widely used in industrial processes. So far, no any phosgene fluorescent sensor has been reported. In this study, we report
Rui Liu et al.
Scientific reports, 2, 813-813 (2012-12-12)
Identifying a critical transition and its leading biomolecular network during the initiation and progression of a complex disease is a challenging task, but holds the key to early diagnosis and further elucidation of the essential mechanisms of disease deterioration at
Wen-Li Li et al.
Inhalation toxicology, 23(13), 842-852 (2011-11-01)
The principal acute mode of action of inhaled phosgene gas is related to an increase alveolar fluid exudation under pathologic conditions. This paper considers some aspects in modeling phosgene-induced acute lung injury (ALI) in an acute rat bioassay and whether
Hong-li Chen et al.
Journal of applied toxicology : JAT, 33(1), 71-77 (2011-08-06)
Phosgene is a poorly water-soluble gas penetrating the lower respiratory tract which can induce acute lung injury characterized by a latent phase of fatal pulmonary edema. Pulmonary edema caused by phosgene is believed to be a consequence of oxidative stress
Christopher Grainge et al.
Clinical toxicology (Philadelphia, Pa.), 48(6), 497-508 (2010-09-21)
Phosgene is a substance of immense importance in the chemical industry. Because of its widespread industrial use, there is potential for small-scale exposures within the workplace, large-scale accidental release, or even deliberate release into a built-up area. This review aims
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