577928

Bis(trimetilsilil) amida de lítio

1 M in toluene

• Sinônimo(s): Hexametildissilazano
• Fórmula linear: [(CH₃)₃Si]₂NLi
• Número CAS: 4039-32-1
• Peso molecular: 167.33
• Beilstein: 3567910
• Número MDL: MFCD00008261
• Código UNSPSC: 12352111
• ID de substância PubChem: 24880899
• NACRES: NA.22

Propriedades

• Nível de qualidade: 200
• concentração: 1 M in toluene
• densidade: 0.860 g/mL at 25 °C
• cadeia de caracteres SMILES: [Li]N([Si](C)(C)C)[Si](C)(C)C
• InChI: 1S/C6H18NSi2.Li/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
• chave InChI: YNESATAKKCNGOF-UHFFFAOYSA-N

Descrição

Descrição geral

Lithium bis(trimethylsilyl)amide solution (LiHMDS) is generally used in organic synthesis as a non-nucleophilic strong Bronsted base.

Aplicação

LiHMDS can be used as a reagent:

• In the deprotonation and nucleophilic difluoromethylation reactions.
• To synthesize isoquinoline derivatives by the addition of N-iodosuccinimide (NIS) to the α-benzyl tosylmethyl isocyanides.
• To prepare arylboronic acid pinacol esters by the reaction of aryl fluorides with bis(pinacolato)diboron via palladium-catalyzed cross-coupling reaction.

Lithium bis(trimethylsilyl)amide is generally used in organic synthesis as a non-nucleophilic strong Brønsted base. It can be used for salt metathesis reaction for the synthesis of cesium bis(trimethylsilyl)amide (CsHMDS) and lithium fluoride by reacting with cesium fluoride.

Informações de segurança

• Pictogramas: GHS02,GHS08,GHS05,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H225,H251,H304,H314,H336,H361d,H373,H412
• Declarações de precaução: P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classificações de perigo: Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 - STOT SE 3
• Órgãos-alvo: Central nervous system
• Perigos de suplementos: EUH014
• Código de classe de armazenamento: 4.2 - Pyrophoric and self-heating hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 48.0 °F - closed cup
• Ponto de fulgor (°C): 8.9 °C - closed cup
• Equipamento de proteção individual: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter