566357

m-Toluenesulfonyl chloride

97%

• Sinônimo(s): 3-Methylbenzenesulfonyl chloride
• Fórmula linear: CH₃C₆H₄SO₂Cl
• Número CAS: 1899-93-0
• Peso molecular: 190.65
• Número MDL: MFCD00051747
• Código UNSPSC: 12352100
• ID de substância PubChem: 24880292
• NACRES: NA.22

Propriedades

• Ensaio: 97%
• índice de refração: n20/D 1.5490 (lit.)
• p.e.: 252-253 °C (lit.)
• densidade: 1.314 g/mL at 25 °C (lit.)
• cadeia de caracteres SMILES: Cc1cccc(c1)S(Cl)(=O)=O
• InChI: 1S/C7H7ClO2S/c1-6-3-2-4-7(5-6)11(8,9)10/h2-5H,1H3
• chave InChI: KFPMLWUKHQMEBU-UHFFFAOYSA-N

Descrição

Descrição geral

m-Toluenesulfonyl chloride can be synthesized via chlorination of m-thiocresol in glacial acetic acid.

Aplicação

m-Toluenesulfonyl chloride may be used in the synthesis of mesityl-m-tolyl sulfone via reaction with mesitylene.

Reactant involved in they synthesis of biologically active molecules including:

• Small molecule ligands for the Stat3 SH2 domain
• Isoindoline-5-propenehydroxamates for use as histone deactylase inhibitors
• Phenyl-pyrazolylamine-based derivatives as FLT3 kinase inhibitors
• Aryldisulfonamides with antibacterial activity
• Quinazoline analogs for the treatment of Gaucher disease
• 17β-HSD2 inhibitors for the treatment of osteoporosis

Informações de segurança

• Pictogramas: GHS05
• Palavra indicadora: Danger
• Frases de perigo: H314
• Declarações de precaução: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Classificações de perigo: Skin Corr. 1B
• Código de classe de armazenamento: 8A - Combustible corrosive hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 225.0 °F - closed cup
• Ponto de fulgor (°C): 107.2 °C - closed cup
• Equipamento de proteção individual: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter