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Sigma-Aldrich

2-Chlorotrityl chloride

≥97.0% (AT)

Sinônimo(s):

Chloro(2-chlorophenyl)diphenylmethane

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About This Item

Fórmula empírica (Notação de Hill):
C19H14Cl2
Número CAS:
42074-68-0
Peso molecular:
313.22
Beilstein:
1983914
Número CE:
255-647-3
Número MDL:
MFCD00040399
Código UNSPSC:
12352100
ID de substância PubChem:
57648180
NACRES:
NA.22

Ensaio

≥97.0% (AT)

forma

solid

pf

130-135 °C

cadeia de caracteres SMILES

Clc1ccccc1C(Cl)(c2ccccc2)c3ccccc3

InChI

1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H

chave InChI

JFLSOKIMYBSASW-UHFFFAOYSA-N

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Aplicação

2-Chlorotrityl chloride was used to obtain protected peptide fragments that can be applied to the preparation of head-to-tail cyclopeptides or to condensation of peptidic fragments.

Outras notas

Protecting group reagent for carboxylic acids forming esters which are cleaved mildly.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Warning

Frases de perigo

H290,H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

8A - Combustible corrosive hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Journal of peptide science : an official publication of the European Peptide Society, 22(11-12), 673-681 (2016-10-05)
Myosin light chain kinase (MLCK) is a key regulator of various forms of cell motility including smooth muscle contraction, cell migration, cytokinesis, receptor capping, secretion, etc. Inhibition of MLCK activity in endothelial and epithelial monolayers using cell-permeant peptide Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys (PIK
Jie Luo et al.
Journal of the American Society for Mass Spectrometry, 30(9), 1643-1653 (2019-06-07)
Chemical cross-linking combined with mass spectrometry (CL-MS) is a powerful method for characterizing the architecture of protein assemblies and for mapping protein-protein interactions. Despite its proven utility, confident identification of cross-linked peptides remains a formidable challenge, especially when the peptides
Sogol Kangarlou et al.
Pharmaceutical biology, 55(1), 277-285 (2016-12-13)
Curcumin, a naturally occurring polyphenol, has been extensively studied for its broad-spectrum anticancer effects. The potential benefits are, however, limited due to its poor water solubility and rapid degradation which result in low bioavailability on administration. This study encapsulates curcumin
Elżbieta Kamysz et al.
Journal of peptide science : an official publication of the European Peptide Society, 18(9), 560-566 (2012-07-13)
LL37 and histatin 5 are antimicrobial peptides. LL37 exhibits killing activity against a broad spectrum of pathogens, whereas histatin 5 is primarily an antifungal agent. Head-to-tail cyclization of histatin 5 did not affect its antimicrobial and haemolytic activity. The cyclic
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