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157201

Sigma-Aldrich

Sodium aurothiomalate hydrate

Sinônimo(s):

(1,2-Dicarboxyethylthio)gold disodium salt hydrate, Gold sodium thiomalate hydrate, Mercaptobutanedioic acid gold(I) disodium salt

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About This Item

Fórmula linear:
NaO2CCH2CH(SAu)CO2Na · xH2O
Peso molecular:
390.08 (anhydrous basis)
Número MDL:
MFCD00166971
Código UNSPSC:
12352100
ID de substância PubChem:
24849665
NACRES:
NA.22

forma

powder

cadeia de caracteres SMILES

O.[Na+].[Na+].[O-]C(=O)CC(S[Au])C([O-])=O

InChI

1S/C4H6O4S.Au.2Na.H2O/c5-3(6)1-2(9)4(7)8;;;;/h2,9H,1H2,(H,5,6)(H,7,8);;;;1H2/q;3*+1;/p-3

chave InChI

YLQOAPBVYJCTPW-UHFFFAOYSA-K

Descrição geral

Sodium aurothiomalate has antirheumatic properties and exhibits inhibitory effects against M. tuberculosis.

Aplicação

Sodium aurothiomalate hydrate was used in the high mobility group box chromosomal protein 1 (HMGB1) western blotting.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H317

Declarações de precaução

P280

Classificações de perigo

Skin Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Gold nanoparticles 20 nm diameter, OD 1, stabilized suspension in 0.1 mM PBS, reactant free

Sigma-Aldrich

753610

Gold nanoparticles

EX-CELL® Antifoam gamma irradiated

SAFC

59920C

EX-CELL® Antifoam

Kathryn E A Lougheed et al.
Tuberculosis (Edinburgh, Scotland), 89(5), 364-370 (2009-08-25)
Mycobacterium tuberculosis has an on-going impact on global public health and new therapeutics to treat tuberculosis are urgently required. The emergence of drug resistant tuberculosis poses a serious threat to the control of this pathogen, and the development of drugs
Cecilia K Zetterström et al.
Journal of leukocyte biology, 83(1), 31-38 (2007-10-05)
Gold compounds such as gold sodium thiomalate (GST) can reduce the symptoms of rheumatoid arthritis (RA), although their mechanism of action is not well defined. As the proinflammatory mediator high mobility group box chromosomal protein 1 (HMGB1) may play a
Christoph Tabeling et al.
Journal of vascular research, 52(4), 279-288 (2016-02-20)
Pulmonary vascular hyperresponsiveness is a main characteristic of pulmonary arterial hypertension (PAH). In PAH patients, elevated levels of the vasoconstrictors thromboxane A2 (TXA2), endothelin (ET)-1 and serotonin further contribute to pulmonary hypertension. Protein kinase C (PKC) isozyme alpha (PKCα) is
Meghan Riddell et al.
Nature communications, 9(1), 5357-5357 (2018-12-19)
Strict regulation of proliferation is vital for development, whereas unregulated cell proliferation is a fundamental characteristic of cancer. The polarity protein atypical protein kinase C lambda/iota (aPKCλ) is associated with cell proliferation through unknown mechanisms. In endothelial cells, suppression of
Farivash Darabi et al.
Journal of inorganic biochemistry, 149, 102-107 (2015-04-14)
Aurothiomalate (AuTm) is an old, clinically established, antiarthritic gold drug that is currently being reconsidered as a candidate drug for cancer treatment and for other therapeutic indications within a more general drug repositioning program. As the biological effects of gold

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