157201
Sodium aurothiomalate hydrate
Sinônimo(s):
(1,2-Dicarboxyethylthio)gold disodium salt hydrate, Gold sodium thiomalate hydrate, Mercaptobutanedioic acid gold(I) disodium salt
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About This Item
Fórmula linear:
NaO2CCH2CH(SAu)CO2Na · xH2O
Peso molecular:
390.08 (anhydrous basis)
Número MDL:
Código UNSPSC:
12352100
ID de substância PubChem:
NACRES:
NA.22
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Formulário
powder
cadeia de caracteres SMILES
O.[Na+].[Na+].[O-]C(=O)CC(S[Au])C([O-])=O
InChI
1S/C4H6O4S.Au.2Na.H2O/c5-3(6)1-2(9)4(7)8;;;;/h2,9H,1H2,(H,5,6)(H,7,8);;;;1H2/q;3*+1;/p-3
chave InChI
YLQOAPBVYJCTPW-UHFFFAOYSA-K
Descrição geral
Sodium aurothiomalate has antirheumatic properties and exhibits inhibitory effects against M. tuberculosis.
Aplicação
Sodium aurothiomalate hydrate was used in the high mobility group box chromosomal protein 1 (HMGB1) western blotting.
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Journal of leukocyte biology, 83(1), 31-38 (2007-10-05)
Gold compounds such as gold sodium thiomalate (GST) can reduce the symptoms of rheumatoid arthritis (RA), although their mechanism of action is not well defined. As the proinflammatory mediator high mobility group box chromosomal protein 1 (HMGB1) may play a
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Journal of inorganic biochemistry, 149, 102-107 (2015-04-14)
Aurothiomalate (AuTm) is an old, clinically established, antiarthritic gold drug that is currently being reconsidered as a candidate drug for cancer treatment and for other therapeutic indications within a more general drug repositioning program. As the biological effects of gold
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